●The potential for novel anti-inflammatory therapies for coronary artery disease Cascieri, M.A. Nature Reviews Drug Discovery February (2002) Inflammation has an important role in the development of atherosclerosis. This article reviews new immunological drug targets arising from an increased understanding of the inflammatory process.

●Time to act Moore, J. P. Nature 24 January (2002) A commentary on the shortcomings of current US government policy on AIDS vaccine development.

●Deadly encounter: ubiquitin meets apoptosis Jesenberger, V. and Jentsch, S. Nature Reviews Molecular Cell Biology (February 2002) Review article on recent work that has revealed a key role for the ubiquitin/proteasome system in the execution of programmed cell death.

●One step forwards, one step back Lifson, J. D. & Martin, M. A. Nature 17 January (2002) News and Views article commenting on recent results in pre-clinical AIDS vaccine studies.

●Secretory lysosomes Blot, E. J. & Griffiths, G. M Nature Reviews Molecular Cell Biology February (2002) This review discusses the dual functions of secretory lysosomes in the secretion and degradation of proteins, and asks how these organelles differ from conventional secretory vesicles and lysosomes.

●A stimulating presentation Dudley, M.E. Nature Biotechnology February (2002)

●Tumor and viral escape from inhibited T cells Welsh, R.M. et al. Nature Immunology February (2002) News and Views article discussing recent evidence that viruses use inhibitory receptors to turn off cytotoxic T cells.

●Focus on ion channel structureNature Reviews Neuroscience February (2002) Reviews in this special issue cover the structure of glutamate receptors, potassium channels and nicotinic acetylcholine receptors.

●Potassium channel structures Choe, S. Nature Reviews Neuroscience February (2002)

●Drosophila innate immunity — new developments Hoffman, J. A. & Reichhart, J. M. Nature Immunology February (2002)