Using human and mouse embryonic stem cells (ESCs), these authors identified an alternatively spliced isoform of the transcription factor FOXP1 that is specific to ESCs and regulates pluripotency. The splicing event alters FOXP1 DNA binding, and this in turn promotes the expression of several transcription factors that are essential for pluripotency. The FOXP1 splice isoform also stimulates the reprogramming of somatic cells and is needed for the efficient production of induced pluripotent stem cells.
ORIGINAL RESEARCH PAPER
Gabut, M. et al. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell 147, 132–146 (2011)
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Flintoft, L. Splicing switch is key to pluripotency. Nat Rev Genet 12, 742 (2011). https://doi.org/10.1038/nrg3106
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DOI: https://doi.org/10.1038/nrg3106
