●Rethinking the central causes of diabetes. Elmquist, J. K. & Marcus, J. N. Nature Medicine June (2003)

●Proteins pure and applied.Nature 22 May (2003) An overview of new products for protein purification, scaled-up production and analysis.

●Mining the genome for combination therapies. Golub, T. R. Nature Medicine May (2003)

●The double puzzle of diabetes. Diamond, J. Nature 5 June (2003)

●Regulation of IL-4 gene expression in T cells and its therapeutic perspectives. Li-Weber, M. & Krammer, P. H. Nature Reviews Immunology July (2003)

●Rethinking clinical trials for cytostatic drugs. Millar, A. W. & Lynch, K. P. Nature Reviews Cancer July (2003)

●Cancer genetics and drug discovery in the zebrafish. Stern, H. M. & Zon, L. I. Nature Reviews Cancer July (2003)

●Turned off by RNA. Kleinjan, D. A. & van Heyningen, V. Nature Genetics June (2003) This News and Views article speculates on the role that antisense-mediated methylation and silencing might play in the manifes- tation of disease.

●ALLHAT: a saga of missed opportunities. McInnes, G. T. Journal of Human Hypertension June (2003)

●Do fluorescent drugs show you more than you wanted to know? McGrath, J. C. & Daly, C. J. British Journal of Pharmacology May (2003)

●Deafening cycle. Baumgartner, B. & Harper, J. W. Nature Cell Biology May (2003) A discussion of new data implicating Cdk inhibitors and inappropriate hair cell proliferation in deafness.

●Special focus: Calcium.Nature Reviews Molecular Cell Biology July (2003)

●Phospholamban: a crucial regulator of cardiac contractility. MacLennan, D. H. & Kranias, E. G.

●Calcium-signalling dynamics, homeostasis and remodelling. Berridge, M. J., Bootman, M. D. & Roderick, H. L.