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Interventional cardiology

Don't neglect the octogenarians—DES for everyone!?

Octogenarians are a growing population of patients undergoing percutaneous coronary intervention (PCI) and, yet, they are under-represented in clinical trials. Wang et al. demonstrate the increasing need for PCI, but declining use of drug-eluting stents in this age group, despite associated reductions in mortality, myocardial infarction, and rehospitalization.

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Figure 1: Incidence of DES use over time stratified according to patient age and type of PCI.

References

  1. Lee, P. Y., Alexander, K. P., Hammill, B. G., Pasquali, S. K. & Peterson, E. D. Representation of elderly persons and women in published randomized trials of acute coronary syndromes. JAMA 286, 708–713 (2001).

    Article  CAS  Google Scholar 

  2. Wang, T. Y. et al. Percutaneous coronary intervention and drug-eluting stent use among patients ≥85 years of age in the United States. J. Am. Coll. Cardiol. 59, 105–112 (2012).

    Article  PubMed  Google Scholar 

  3. Kastrati, A. et al. Analysis of 14 trials comparing sirolimus-eluting stents with bare-metal stents. N. Engl. J. Med. 356, 1030–1039 (2007).

    Article  CAS  Google Scholar 

  4. Aziz, A. et al. Evaluation of revascularization subtypes in octogenarians undergoing coronary artery bypass grafting. Circulation 120 (11 Suppl.), S65–S69 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Kozower, B. D. et al. Impact of complete revascularization on long-term survival after coronary artery bypass grafting in octogenarians. Ann. Thorac. Surg. 80, 112–116 (2005).

    Article  PubMed  Google Scholar 

  6. McKellar, S. H., Brown, M. L., Frye, R. L., Schaff, H. V. & Sundt, T. M. 3rd Comparison of coronary revascularization procedures in octogenarians: a systematic review and meta-analysis. Nat. Clin. Pract. Cardiovasc. Med. 5, 738–746 (2008).

    Article  Google Scholar 

  7. Singh, M. et al. Mayo Clinic Risk Score for percutaneous coronary intervention predicts in-hospital mortality in patients undergoing coronary artery bypass graft surgery. Circulation 117, 356–362 (2008).

    Article  PubMed  Google Scholar 

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Both authors researched data for the article, contributed to the discussion of the content and reviewed/edited the article before submission. M. Gössl wrote the article.

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Correspondence to David R. Holmes Jr.

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The authors declare no competing financial interests.

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Gössl, M., Holmes, D. Don't neglect the octogenarians—DES for everyone!?. Nat Rev Cardiol 9, 189–190 (2012). https://doi.org/10.1038/nrcardio.2012.22

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