●Engineering the 6 million dollar T cell. Pardoll, D. Nature Biotechnology December (2002) This News and Views article describes new bispecific T cells that boost antitumour immunity.

●uPAR: a versatile signalling orchestrator. Blasi, F. & Carmeliet, P. Nature Reviews Molecular Cell Biology December (2002)

●Outfoxing the blood vessel. O'Reilly, M. S. Nature Medicine December (2002) A News and Views article discussing two papers in the same issue that examine new ways to manipulate angiogenesis – including a vaccination approach.

●Pluripotency and tumorigenicity. Brickman, J. & Burdon, T. Nature Genetics December (2002) This News and Views article describes how the tumour suppressor Apc modulates embryonic stem-cell differentiation by regulating β-catenin signalling.

●Blocking NO synthesis: how, where and why? Vallance, P. & Leiper, J. Nature Reviews Drug Discovery December (2002)

●Dual-specificity phosphatases as targets for antineoplastic agents. Lyon, M. A., Ducruet, A. P., Wipf, P. & Lazo, J. S. Nature Reviews Drug Discovery December (2002)

●Checkpoint signalling: focussing on 53BP1. Araham, R. T. Nature Cell Biology December (2002) This News and Views article discusses how p53BP1 functions at the G2/M checkpoint in cancer and normal cells.

●Crowd control in the crypt. Booth, C., Brady, G. & Potten, C. S. Nature Medicine December (2002) This News and Views article discusses how the TGF-β/β-catenin signalling pathway regulates differentiation and determines the location of cancer cells within the intestinal crypts.