Cancer genomic information can provide considerable detail on the evolutionary history of a tumour. However, as epigenetic alterations might contribute to tumour evolution, a more complete picture requires epigenomic analyses. DNA methylation dynamics in low-grade gliomas and matched recurrences indicated that epigenetic changes and somatic mutations evolved in parallel to deregulate the cell cycle. This phyloepigenetic analysis recapitulated phylogenetics and suggests co-dependency of epigenetic and genetic events.
References
Mazor, T., Pankov, A. et al. DNA methylation and somatic mutations converge on the cell cycle and define similar evolutionary histories in brain tumors. Cancer Cell 28, 307–317 (2015)
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Seton-Rogers, S. Genetic and epigenetic co-dependency. Nat Rev Cancer 15, 637 (2015). https://doi.org/10.1038/nrc4040
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DOI: https://doi.org/10.1038/nrc4040