Cancer genomic information can provide considerable detail on the evolutionary history of a tumour. However, as epigenetic alterations might contribute to tumour evolution, a more complete picture requires epigenomic analyses. DNA methylation dynamics in low-grade gliomas and matched recurrences indicated that epigenetic changes and somatic mutations evolved in parallel to deregulate the cell cycle. This phyloepigenetic analysis recapitulated phylogenetics and suggests co-dependency of epigenetic and genetic events.