Histopathological analyses and intraoperative magnetic resonance imaging are both used for diagnosis and to define tumour margins during brain tumour surgery, but they have limitations. Eberlin et al. developed a strategy using desorption electrospray ionization mass spectrometry (DESI-MS) to analyse lipid profiles, which may improve brain tumour diagnosis and the definition of tumour margins. This was validated using 32 surgical specimens from five patients.
ORIGINAL RESEARCH PAPER
Eberlin, L. S. et al. Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors. Proc. Natl Acad. Sci. USA 8 Jan 2013 (doi:10.1073/pnas.1215687110)
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On the edge. Nat Rev Cancer 13, 81 (2013). https://doi.org/10.1038/nrc3467
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DOI: https://doi.org/10.1038/nrc3467