A semilinear amplification method allows uniform amplification across a single cell's genome.
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References
Lu, S. et al. Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing. Science 338, 1627–1630 (2012).
Zong, C. et al. Genome-wide detection of single-nucleotide and copy-number variations of a single human cell. Science 338, 1622–1626 (2012).
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Rusk, N. Single cells go fully genomic. Nat Methods 10, 190–191 (2013). https://doi.org/10.1038/nmeth.2391
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DOI: https://doi.org/10.1038/nmeth.2391