Virus-triggered type I interferon induces the lysine methyltransferase Setdb2; this then generates repressive histone marks on the promoters of genes encoding molecules important for antibacterial immunity. This process can contribute to influenza virus–associated bacterial superinfection.
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Wack, A. Stop the executioners. Nat Immunol 16, 6–8 (2015). https://doi.org/10.1038/ni.3055
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DOI: https://doi.org/10.1038/ni.3055
