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Synthetic biology

Tailor-made genetic codes

Nature Chemistry volume 8, pages 291–292 (2016)Cite this article

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Expanding the range of amino acids polymerizable by ribosomes could enable new functionalities to be added to polypeptides. Now, the genetic code has been reprogrammed using a reconstituted in vitro translation system to enable synthesis of unnatural peptides with unmatched flexibility.

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Figure 1: Reprogramming the genetic code.

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Authors and Affiliations

  1. Michael C. Jewett is in the Department of Chemical and Biological Engineering and the Center for Synthetic Biology at Northwestern University, Evanston, Illinois 60208, USA,

    Michael C. Jewett

  2. Vincent Noireaux is at the University of Minnesota, Minneapolis, Minnesota 55455, USA,

    Vincent Noireaux

Authors
  1. Michael C. Jewett
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  2. Vincent Noireaux
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Corresponding authors

Correspondence to Michael C. Jewett or Vincent Noireaux.

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Jewett, M., Noireaux, V. Tailor-made genetic codes. Nature Chem 8, 291–292 (2016). https://doi.org/10.1038/nchem.2484

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