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Spotlight on Perspective on Stem Cell Homing and Mobilization

Hematopoietic stem cell mobilization: updated conceptual renditions

Leukemia volume 27, pages 24–31 (2013)Cite this article

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Abstract

Despite its specific clinical relevance, the field of hematopoietic stem cell mobilization has received broad attention, owing mainly to the belief that pharmacologic stem cell mobilization might provide clues as to how stem cells are retained in their natural environment, the bone marrow ‘niche’. Inherent to this knowledge is also the desire to optimally engineer stem cells to interact with their target niche (such as after transplantation), or to lure malignant stem cells out of their protective niches (in order to kill them), and in general to decipher the niche’s structural components and its organization. Whereas, with the exception of the recent addition of CXCR4 antagonists to the armamentarium for mobilization of patients refractory to granulocyte colony-stimulating factor alone, clinical stem cell mobilization has not changed significantly over the last decade or so, much effort has been made trying to explain the complex mechanism(s) by which hematopoietic stem and progenitor cells leave the marrow. This brief review will report some of the more recent advances about mobilization, with an attempt to reconcile some of the seemingly inconsistent data in mobilization and to interject some commonalities among different mobilization regimes.

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Acknowledgements

Susanne Bräuninger and Darja Karpova are acknowledged for assembly of the mobilization data shown in Figure 1. HB acknowledges research funding by the German Federal Ministry for Education and Research (BMBF, Ci3), the Federal State of Hesse (LOEWE CGT and LOEWE OSF), Deutsche Krebshilfe 108031 and DFG BO 3553/1-1. TP’s research is funded through NIH Grants HL58734 and DK094702.

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  1. Department of Medicine/Division of Hematology, University of Washington, Seattle, WA, USA

    H Bonig & T Papayannopoulou

  2. Department of Cellular Therapeutics/Cell processing, German Red Cross Blood Service Baden-Württemberg-Hesse and Institute for Transfusion Medicine and Immunohematology, Clinics of the Goethe University Medical School, Frankfurt, Germany

    H Bonig

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Bonig, H., Papayannopoulou, T. Hematopoietic stem cell mobilization: updated conceptual renditions. Leukemia 27, 24–31 (2013). https://doi.org/10.1038/leu.2012.254

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