Abstract
Population-based personal exposures to particulate matter (PM) and personal-ambient relationships of PM and component concentrations for outpatients with COPD and/or asthma were investigated in New York City (NYC) and Seattle for thoracic PM (PM10) and fine PM (PM2.5). Measurements of outdoor, indoor, and personal PM10 and PM2.5 concentrations were made concurrently for 12-consecutive days at 24 patients’ residences. Filters were analyzed for elemental components, using XRF and black carbon (BC), by reflectance. Daily morning and evening measurements of heart rate (HR) and blood oxygen saturation (SpO2) by pulse oximeter, and forced expiratory volume in 1 s (FEV1) and peak expiratory flowrate (PEF) by spirometry were also measured, and symptom data were collected. Central monitoring site, outdoor, indoor, and personal concentration-response relationships of PM2.5, PM10−2.5, and their components were examined using mixed-effect models. The relatively small sample size of the study limited the interpretation of results, but of the PM chemical components examined, only nickel concentrations showed consistent associations, and only with HR in the NYC COPD patients.
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Acknowledgements
This research was a part of a doctoral thesis of Shao-I Hsu, under the guidance of Drs. Morton Lippmann and Kazuhiko Ito, her thesis advisors. The field data in NYC were collected by Dr. Hsu, Dr. Michaela Kendall, and Ms. Patricia Lopez. The field data in Seattle were provided by Karen Jansen, Jane Koenig and Timothy Larson. The project was supported by a Cooperative Agreement with the U.S. Environmental Protection Agency (CR 827164), in collaboration with Dr. Lance Wallace of EPA. It is part of a Center Program supported by the National Institute of Environmental Health Science (Grant ES 00260). The research conducted at the University of Washington was supported, in part, by a Cooperative Agreement with the U.S. Environmental Protection Agency EPA CR 827355.
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Hsu, SI., Ito, K. & Lippmann, M. Effects of thoracic and fine PM and their components on heart rate and pulmonary function in COPD patients. J Expo Sci Environ Epidemiol 21, 464–472 (2011). https://doi.org/10.1038/jes.2011.7
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DOI: https://doi.org/10.1038/jes.2011.7
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