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Association of HLA and TNF polymorphisms with the outcome of HBV infection in the South Indian population

Genes & Immunity volume 12, pages 552–558 (2011)Cite this article

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Abstract

The role of host genetic factors in the pathogenesis and outcome of hepatitis B virus (HBV) infection is not well known. We assessed the association of HLA and TNF (rs361525, rs1800629, rs1799724, rs1800630 and rs1799964) polymorphisms with HBV outcome in the South Indian population. Association of HLA polymorphism was analyzed in 90 individuals from each group, that is, spontaneous recovery (SR) and chronic-HBV (C-HBV) infection. The role of TNF polymorphisms was evaluated in 150 subjects with SR and 137 patients with C-HBV infection. After adjusting for age and sex, HLA-DRB1*07:01 was strongly associated with chronicity (corrected P-value (pc) <0.005, odds ratio (OR) 3.76, 95% confidence interval (CI) 1.84–7.68). The rs1800630 genotype was associated with HBV outcome in codominant (pc<0.01, OR=1.99, 95% CI 1.30–3.05) and dominant (pc<0.01, OR=2.28, 95% CI 1.35–3.84) analyzing models after adjusting for age and sex. Similarly, the rs1799964 genotype was associated with HBV outcome in codominant (pc=0.01, OR=1.57, 95% CI 1.09–2.27) and dominant (pc<0.01, OR=2.21, 95% CI 1.27–3.83) analyzing models. Haplotype analysis (rs1799964/rs1800630/rs1799724/rs1800629/rs361525) revealed that the CACGG haplotype was strongly associated with C-HBV infection (P=0.0004). Our study suggests that inheritance of HLA and TNF polymorphisms might explain the outcome of HBV infection in the South Indian population.

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Acknowledgements

We specially extend our gratitude to the staff of virology and all participants in our study. The study of TNF polymorphism was funded by a Fluid Research Grant (Grant No. 5821) from the Christian Medical College, Vellore. The study of HLA polymorphism with the outcome of HBV infection was funded by DBT Grant (BT/PR10280/MED/29/58/2007).

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Authors and Affiliations

  1. Department of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, India

    G J Fletcher, J Christdas, M Gnanamony, A M Ismail, R Anantharam, R Kannangai & P Abraham

  2. Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India

    P Samuel

  3. Department of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India

    C E Eapen

  4. Department of Transfusion Medicine and Immunohaematology, Christian Medical College, Vellore, Tamil Nadu, India

    M P Chacko & D Daniel

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  1. G J Fletcher
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Correspondence to P Abraham.

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Fletcher, G., Samuel, P., Christdas, J. et al. Association of HLA and TNF polymorphisms with the outcome of HBV infection in the South Indian population. Genes Immun 12, 552–558 (2011). https://doi.org/10.1038/gene.2011.32

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