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| Open AccessEtazene induces developmental toxicity in vivo Danio rerio and in silico studies of new synthetic opioid derivative
- Łukasz Kurach
- , Agnieszka Chłopaś-Konowałek
- & Anna Boguszewska-Czubara
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| Open AccessThree dimensional and microphysiological bone marrow models detect in vivo positive compounds
- Rhiannon David
- , Sarah Gee
- & Ann Doherty
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| Open AccessAssessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase
- Tena Čadež
- , Dora Kolić
- & Zrinka Kovarik
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| Open AccessQuantitative assessment of sensitizing potency using a dose–response adaptation of GARDskin
- Robin Gradin
- , Andy Forreryd
- & Henrik Johansson
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| Open AccessBisphenol-A in biological samples of breast cancer mastectomy and mammoplasty patients and correlation with levels measured in urine and tissue
- Razieh Keshavarz-Maleki
- , Ahmad Kaviani
- & Omid Sabzevari
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| Open AccessEvaluation of acute and subacute toxicity of ethanolic extract and fraction of alkaloids from bark of Aspidosperma nitidum in mice
- Heliton Patrick Cordovil Brígido
- , Everton Luiz Pompeu Varela
- & Sandro Percário
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| Open AccessTargeting ROS/NF-κB signaling pathway by the seedless black Vitis vinifera polyphenols in CCl4-intoxicated kidney, lung, brain, and spleen in rats
- Noha H. Habashy
- , Ahmad S. Kodous
- & Marwa M. Abu-Serie
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| Open AccessScale-up approach for supercritical fluid extraction with ethanol–water modified carbon dioxide on Phyllanthus niruri for safe enriched herbal extracts
- Norsyamimi Hassim
- , Masturah Markom
- & Shuhaida Harun
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| Open AccessIsoflurane impairs oogenesis through germ cell apoptosis in C. elegans
- Tao Zhang
- , Cheng Ni
- & Zhongcong Xie
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| Open AccessHerbicidal properties of antihypertensive drugs: calcium channel blockers
- Hannan Safiyyah Tan Sian Hui Abdullah
- , Poh Wai Chia
- & Tse Seng Chuah
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| Open AccessGenome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity
- Valerie Sapp
- , Aitor Aguirre
- & Mohit Jain
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| Open AccessNeonatal administration of a subanaesthetic dose of JM-1232(−) in mice results in no behavioural deficits in adulthood
- Koji Iwanaga
- , Yasushi Satoh
- & Takehiko Ikeda
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| Open AccessA genome-wide portrait of pervasive drug contaminants
- Joseph Uche Ogbede
- , Guri Giaever
- & Corey Nislow
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| Open AccessCharacterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis
- Ann-Yae Na
- , Jung Jae Jo
- & Sangkyu Lee
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| Open AccessZinc oxide nanoparticles improve testicular steroidogenesis machinery dysfunction in benzo[α]pyrene-challenged rats
- Niveen M. Daoud
- , Mohamed S. Aly
- & Naglaa A. Ali
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| Open AccessUrinary microRNAs as non-invasive biomarkers for toxic acute kidney injury in humans
- Fathima Shihana
- , Wilson K. M. Wong
- & Nicholas A. Buckley
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| Open AccessDevelopment of an objective index, neural activity score (NAS), reveals neural network ontogeny and treatment effects on microelectrode arrays
- Austin P. Passaro
- , Onur Aydin
- & Steven L. Stice
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| Open AccessUse of omeprazole, the proton pump inhibitor, as a potential therapy for the capecitabine-induced hand-foot syndrome
- Shiori Hiromoto
- , Takehiro Kawashiri
- & Takao Shimazoe
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| Open AccessGenotoxic and oxidative effect of duloxetine on mouse brain and liver tissues
- Isela Álvarez-González
- , Scarlett Camacho-Cantera
- & Eduardo Madrigal-Bujaidar
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| Open AccessA dose-escalating toxicology study of the candidate biologic ELP-VEGF
- Jamarius P. Waller
- , Stephen P. Burke
- & Gene L. Bidwell III
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| Open AccessPerformance of preclinical models in predicting drug-induced liver injury in humans: a systematic review
- Hubert Dirven
- , Gunn E. Vist
- & Katya Tsaioun
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| Open AccessConcomitant drugs associated with increased mortality for MDMA users reported in a drug safety surveillance database
- Isaac V. Cohen
- , Tigran Makunts
- & Kelan Thomas
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| Open AccessEvaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug
- Jason Darmadi
- , Razethy Rahayu Batubara
- & Kholis Abdurachim Audah
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| Open AccessA versatile, compartmentalised gut-on-a-chip system for pharmacological and toxicological analyses
- Pim de Haan
- , Milou J. C. Santbergen
- & Elisabeth Verpoorte
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| Open AccessOlanzapine induced reproductive toxicity in male rats
- Cankız Mina Ardıç
- , Sinem Ilgın
- & Özlem Atlı-Eklioğlu
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| Open AccessPredicting exposure concentrations of chemicals with a wide range of volatility and hydrophobicity in different multi-well plate set-ups
- Julita Stadnicka-Michalak
- , Nadine Bramaz
- & Kristin Schirmer
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| Open AccessArsenic hexoxide has differential effects on cell proliferation and genome-wide gene expression in human primary mammary epithelial and MCF7 cells
- Donguk Kim
- , Na Yeon Park
- & Heeyoun Bunch
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| Open AccessTransforming early pharmaceutical assessment of genotoxicity: applying statistical learning to a high throughput, multi end point in vitro micronucleus assay
- Amy Wilson
- , Piotr Grabowski
- & Ann Doherty
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| Open AccessCyclophosphamide arrhythmogenicitytesting using human-induced pluripotent stem cell-derived cardiomyocytes
- A. D. Podgurskaya
- , M. M. Slotvitsky
- & K. I. Agladze
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| Open AccessThiamethoxam exposure deregulates short ORF gene expression in the honey bee and compromises immune response to bacteria
- Pâmela Decio
- , Pinar Ustaoglu
- & Matthias Soller
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| Open AccessCombination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity
- Masashi Arita
- , Satoshi Watanabe
- & Toshiaki Kikuchi
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| Open AccessPrediction of pharmacological activities from chemical structures with graph convolutional neural networks
- Miyuki Sakai
- , Kazuki Nagayasu
- & Shuji Kaneko
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| Open AccessHigher efficacy and reduced adverse reactions in neoadjuvant chemotherapy for breast cancer by using pegylated liposomal doxorubicin compared with pirarubicin
- Weifang Liu
- , Wei Chen
- & Aiping Shi
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| Open AccessPreclinical safety and immunogenicity of Streptococcus pyogenes (Strep A) peptide vaccines
- Simone Reynolds
- , Manisha Pandey
- & Michael Good
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| Open AccessEvaluation of a panel of spermatological methods for assessing reprotoxic compounds in multilayer semen plastic bags
- M. Schulze
- , F. Schröter
- & U. Jakop
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| Open AccessDietary zinc enrichment reduces the cadmium burden of mealworm beetle (Tenebrio molitor) larvae
- Claudia Keil
- , Maria Maares
- & Hajo Haase
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| Open AccessThe safety profile of Bald’s eyesalve for the treatment of bacterial infections
- Blessing O. Anonye
- , Valentine Nweke
- & Freya Harrison
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| Open AccessNebulized ivermectin for COVID-19 and other respiratory diseases, a proof of concept, dose-ranging study in rats
- Carlos Chaccour
- , Gloria Abizanda
- & Ana Gloria Gil
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| Open AccessPreparation, characterisation and biological evaluation of biopolymer-coated multi-walled carbon nanotubes for sustained-delivery of silibinin
- Julia Meihua Tan
- , Saifullah Bullo
- & Mohd Zobir Hussein
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| Open AccessSlow-binding reversible inhibitor of acetylcholinesterase with long-lasting action for prophylaxis of organophosphate poisoning
- Oksana A. Lenina
- , Irina V. Zueva
- & Konstantin A. Petrov
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| Open AccessCorrelation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides
- Ines Greco
- , Natalia Molchanova
- & Johan Svenson
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Article
| Open AccessThe prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A
- Shuangshuang Wu
- , Dongyan Huang
- & Zuyue Sun
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| Open AccessA model-based analysis of phenytoin and carbamazepine toxicity treatment using binding-competition during hemodialysis
- Vaibhav Maheshwari
- , Robert S. Hoffman
- & Peter Kotanko
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| Open AccessToxicity of fluralaner, a companion animal insecticide, relative to industry-leading agricultural insecticides against resistant and susceptible strains of filth flies
- Edwin R. Burgess
- , Christopher J. Geden
- & Jeffrey G. Scott
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| Open AccessA new ingestion bioassay protocol for assessing pesticide toxicity to the adult Japanese orchard bee (Osmia cornifrons)
- Ngoc T. Phan
- , Neelendra K. Joshi
- & David J. Biddinger
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| Open AccessDrug response analysis for scaffold-free cardiac constructs fabricated using bio-3D printer
- Kenichi Arai
- , Daiki Murata
- & Koichi Nakayama
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| Open AccessRepeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents
- Ni Lin
- , Xiaobing Zhou
- & Bo Li
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| Open AccessEndocrine disrupter chemicals affect the humoral antimicrobial activities of gilthead seabream males even upon the cease of the exposure
- Yulema Valero
- , Amanda E. López-Cánovas
- & Elena Chaves-Pozo
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| Open AccessIn-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o
- Leonard Blum
- , Sheraz Gul
- & Susanne Schiffmann