Featured
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Review Article |
Rethinking our approach to cancer metabolism to deliver patient benefit
- Saverio Tardito
- & Craig MacKay
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Article
| Open AccessIn silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer
- Marcos Quintela
- , David W. James
- & Lewis W. Francis
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Article
| Open AccessAzithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics
- Naoharu Takano
- , Masaki Hiramoto
- & Keisuke Miyazawa
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Article
| Open AccessSelective inhibition of HDAC6 promotes bladder cancer radiosensitization and mitigates the radiation-induced CXCL1 signalling
- Yu-Chieh Tsai
- , Tzu-Yin Wang
- & Sheng-Fang Su
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Article |
An antibody–drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer
- Joan Jacob
- , Liezl E. Francisco
- & Kendra S. Carmon
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Article |
Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity
- Jun-Kyu Byun
- , Sun Hee Lee
- & You Mie Lee
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Perspective |
Targeting the untargetable: RB1-deficient tumours are vulnerable to Skp2 ubiquitin ligase inhibition
- Pranav Gupta
- , Hongling Zhao
- & Edward L. Schwartz
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Article |
The role of anlotinib-mediated EGFR blockade in a positive feedback loop of CXCL11-EGF-EGFR signalling in anaplastic thyroid cancer angiogenesis
- Juyong Liang
- , Zhijian Jin
- & Weihua Qiu
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Perspective
| Open AccessMolecularly profiled trials: toward a framework of actions for the “nil actionables”
- Allan Michael Jordan
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Article |
Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents
- Xing Xu
- , Yao Wang
- & Peter W. Gunning
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Article
| Open AccessTranscriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin
- Simon R. Lord
- , Jennifer M. Collins
- & Adrian L. Harris
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Article
| Open AccessIntegrated analysis of multiple receptor tyrosine kinases identifies Axl as a therapeutic target and mediator of resistance to sorafenib in hepatocellular carcinoma
- David J. Pinato
- , Matthew W. Brown
- & Rohini Sharma
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Article
| Open AccessInhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs
- Giulia Dell’Omo
- , Daniela Crescenti
- & Paolo Ciana
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Article
| Open AccessTargeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents
- Malgorzata Bajor
- , Agata O. Zych
- & Radoslaw Zagozdzon
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Translational Therapeutics
| Open AccessA novel inhibitory anti-invasive MAb isolated using phenotypic screening highlights AnxA6 as a functionally relevant target protein in pancreatic cancer
- Dermot O'Sullivan
- , Paul Dowling
- & Annemarie Larkin
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Translational Therapeutics
| Open AccessSKLB188 inhibits the growth of head and neck squamous cell carcinoma by suppressing EGFR signalling
- Mansoureh Barzegar
- , Shuang Ma
- & Shile Huang
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Translational Therapeutics
| Open AccessRNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses
- Saoirse O Dolly
- , Mark D Gurden
- & Spiros Linardopoulos
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Translational Therapeutics
| Open AccessIdentification of novel vascular targets in lung cancer
- X Zhuang
- , J M J Herbert
- & R Bicknell
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Translational Therapeutics
| Open AccessA leukotriene B4 receptor-2 is associated with paclitaxel resistance in MCF-7/DOX breast cancer cells
- H Kim
- , G-S Park
- & J-H Kim
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Molecular Diagnostics
| Open AccessExpression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients’ survival
- J Ren
- , W Li
- & Z Xu
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Mini Review
| Open AccessOncogenic AKTivation of translation as a therapeutic target
- A C Hsieh
- , M L Truitt
- & D Ruggero
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Mini Review
| Open AccessMitochondrial recoupling: a novel therapeutic strategy for cancer?
- G Baffy
- , Z Derdak
- & S C Robson
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Translational Therapeutics
| Open AccessD -Glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo- E V Grigorieva
- , T Y Prudnikova
- & E R Zabarovsky
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Molecular Diagnostics
| Open AccessHepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro
- G Wu
- , F Yu
- & E Song
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Translational Therapeutics
| Open AccessTargeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration
- Z I Thomas
- , W Gibson
- & K P Williams
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Molecular Diagnostics
| Open AccessFactor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis
- M N Khan
- , T Bhattacharyya
- & S Kiriakidis
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Molecular Diagnostics
| Open AccessThymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors
- I V Bijnsdorp
- , F Capriotti
- & G J Peters
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Translational Therapeutics
| Open AccessTargeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease
- B H Kang
- , M Tavecchio
- & D C Altieri
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Translational Therapeutics
| Open AccessThe role of tumour-derived iNOS in tumour progression and angiogenesis
- V Kostourou
- , J E Cartwright
- & S P Robinson
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Molecular Diagnostics
| Open AccessANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines
- C Ayoub
- , C Wasylyk
- & B Wasylyk
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Translational Therapeutics
| Open AccessFibroblast growth factor receptor 3-IIIc mediates colorectal cancer growth and migration
- G Sonvilla
- , S Allerstorfer
- & B Marian
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Molecular Diagnostics
| Open AccessMEPE/OF45 as a new target for sensitizing human tumour cells to DNA damage inducers
- P Zhang
- , H Wang
- & Y Wang
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Translational Therapeutics
| Open AccessC20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer
- K Yamaguchi
- , M Sakai
- & Y Furukawa