Integrins articles within Nature Materials

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• Article
  14 September 2023 | Open Access

  The laminin–keratin link shields the nucleus from mechanical deformation and signalling

  Laminin, an important component of the extracellular matrix supporting the epithelium, hinders the typical mechanoresponse of epithelial cells to an increase in substrate stiffness, by protecting the cell nucleus from mechanical deformation.

  • Zanetta Kechagia
  • , Pablo Sáez
  •  & Pere Roca-Cusachs

• Article | 20 January 2020

  Protease-activated receptor signalling initiates α₅β₁-integrin-mediated adhesion in non-haematopoietic cells

  As in haematopoietic cells and platelets, agonist binding to protease-activated receptors PAR1 and PAR2 in non-haematopoietic cells also triggers signalling pathways that lead to α₅β₁-integrin-mediated cell adhesion.

  • Patrizia M. Spoerri
  • , Nico Strohmeyer
  •  & Daniel J. Müller

• News & Views | 20 November 2019

  Building nanobridges for cell adhesion

  Nanofibre mimetic substrates reveal the presence of integrin nanoclusters bridged by unliganded receptors during early cell–matrix adhesion.

  • E. Ada Cavalcanti-Adam

• News & Views | 19 June 2019

  Platelet mechanosensing axis revealed

  An intermediate affinity state of integrin α_IIBβ₃ has been identified to be a key player in platelet mechanosignalling.

  • X. Frank Zhang
  •  & Xuanhong Cheng

• Article | 25 March 2019

  An integrin α_IIbβ₃ intermediate affinity state mediates biomechanical platelet aggregation

  An intermediate affinity state of integrins on platelets has been identified to be induced by a biomechanical activation pathway and is shown to promote platelet aggregation.

  • Yunfeng Chen
  • , Lining Arnold Ju
  •  & Cheng Zhu

• News & Views | 01 December 2017

  Instant integrin mechanosensing

  Single-cell force spectroscopy reveals rapid, biphasic integrin activation and reinforcement of cell–matrix bonds during the initial steps of fibroblast adhesion.

  • Ning Wang

• Article | 06 November 2017

  Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second

  Integrins play an important role in the adhesion of cells to their matrix. Here, the authors investigate how fibroblasts respond to mechanical loads, at the onset of cell adhesion to fibronectin, in distinct phases that are modulated by integrins.

  • Nico Strohmeyer
  • , Mitasha Bharadwaj
  •  & Daniel J. Müller

• Article | 01 May 2017

  EGFR and HER2 activate rigidity sensing only on rigid matrices

  Epidermal growth factor receptor and its isoform HER2 are recruited to nascent cellular adhesion sites and play an important role in the rigidity sensing of cells on stiff substrates, this activity being dependent on Src-mediated phosphorylation.

  • Mayur Saxena
  • , Shuaimin Liu
  •  & Michael P. Sheetz

• News & Views | 21 May 2014

  Sensing rigidity

  Cells use differences in the binding rates between the extracellular matrix and integrin adhesion receptors to sense matrix rigidity.

  • José R. García
  •  & Andrés J. García