Translational Therapeutics
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Open Access
Featured
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Molecular Diagnostics
| Open AccessKRAS, NRAS, BRAF mutation comparison of endoscopic and surgically removed primary CRC paired samples: is endoscopy biopsy material adequate for molecular evaluation?
- Z Saridaki
- , X Saegart
- & S Tejpar
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Genetics and Genomics
| Open AccessTarget gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation
- Manuela Pinheiro
- , Carla Pinto
- & Manuel R Teixeira
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Translational Therapeutics
| Open AccessBRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts
- I Lohse
- , A Borgida
- & D W Hedley
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Short Communication
| Open AccessImpact of KRAS codon subtypes from a randomised phase II trial of selumetinib plus docetaxel in KRAS mutant advanced non-small-cell lung cancer
- P A Jänne
- , I Smith
- & P Smith
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Molecular Diagnostics
| Open AccessMicrosatellite instable vs stable colon carcinomas: analysis of tumour heterogeneity, inflammation and angiogenesis
- L De Smedt
- , J Lemahieu
- & X Sagaert
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Short Communication
| Open AccessDroplet digital PCR measurement of HER2 in patients with gastric cancer
- H Kinugasa
- , K Nouso
- & K Yamamoto
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Genetics and Genomics
| Open AccessActivating GNAS and KRAS mutations in gastric foveolar metaplasia, gastric heterotopia, and adenocarcinoma of the duodenum
- A Matsubara
- , R Ogawa
- & S Sekine
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Genetics and Genomics
| Open AccessTruncating mutations of PPM1D are found in blood DNA samples of lung cancer patients
- A Zajkowicz
- , D Butkiewicz
- & M Rusin
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Genetics and Genomics
| Open AccessAssessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients
- S Q Wong
- , A Fellowes
- & S B Fox
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Molecular Diagnostics
| Open AccessKRAS and BRAF mutations are prognostic biomarkers in patients undergoing lung metastasectomy of colorectal cancer
- S Renaud
- , B Romain
- & G Massard
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Genetics and Genomics
| Open AccessA high incidence of WT1 abnormality in bilateral Wilms tumours in Japan, and the penetrance rates in children with WT1 germline mutation
- Y Kaneko
- , H Okita
- & M Fukuzawa
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Genetics and Genomics
| Open AccessLow-level constitutional mosaicism of a de novoBRCA1 gene mutation
- E Friedman
- , N Efrat
- & S Topper
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Short Communication
| Open AccessAssociation between KRAS mutation and lung metastasis in advanced colorectal cancer
- A A L Pereira
- , J F M Rego
- & S Kopetz
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Genetics and Genomics
| Open AccessMutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations
- S Deb
- , S Q Wong
- & S B Fox
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Genetics and Genomics
| Open AccessTERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations
- M Labussière
- , A L Di Stefano
- & M Sanson
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Letter to the Editor
| Open AccessCoexistence of KRAS mutation with mutant but not wild-type EGFR predicts response to tyrosine-kinase inhibitors in human lung cancer
- A Choughule
- , R Sharma
- & A Dutt
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Genetics and Genomics
| Open AccessThe impact of a BRCA2 mutation on mortality from screen-detected prostate cancer
- M R Akbari
- , C J D Wallis
- & R K Nam
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Clinical Study
| Open AccessOverall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers
- T Golan
- , Z S Kanji
- & S Gallinger
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Molecular Diagnostics
| Open AccessUnique volatolomic signatures of TP53 and KRAS in lung cells
- M P A Davies
- , O Barash
- & H Haick
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Genetics and Genomics
| Open AccessAssessing standardization of molecular testing for non-small-cell lung cancer: results of a worldwide external quality assessment (EQA) scheme for EGFR mutation testing
- S Patton
- , N Normanno
- & E Thunnissen
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Reply to Letter to the Editor
| Open AccessReply: Intra-patient heterogeneity of BRAF mutation status: fact or fiction?
- L Heinzerling
- , G Schuler
- & R Schneider-Stock
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Epidemiology
| Open AccessCoexistence of EGFR with KRAS, or BRAF, or PIK3CA somatic mutations in lung cancer: a comprehensive mutation profiling from 5125 Chinese cohorts
- S Li
- , L Li
- & N Liang
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Genetics and Genomics
| Open AccessErroneous identification of APOBEC3-edited chromosomal DNA in cancer genomics
- R Suspène
- , V Caval
- & J-P Vartanian
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Short Communication
| Open AccessMutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas
- N Mäkinen
- , H-R Heinonen
- & L A Aaltonen
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Genetics and Genomics
| Open AccessPrognostic impact of genomic instability in colorectal cancer
- T S Hveem
- , M A Merok
- & H E Danielsen
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Molecular Diagnostics
| Open AccessClinicopathological and prognostic significance of interleukin-8 expression and its relationship to KRAS mutation in lung adenocarcinoma
- N Sunaga
- , K Kaira
- & M Yamada
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Genetics and Genomics
| Open AccessFocal amplification of the androgen receptor gene in hormone-naive human prostate cancer
- S Merson
- , Z H Yang
- & J P Clark
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Molecular Diagnostics
| Open AccessFGFR2 amplification has prognostic significance in gastric cancer: results from a large international multicentre study
- X Su
- , P Zhan
- & E Kilgour
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Genetics and Genomics
| Open AccessMutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: detection of an activating mutation in the TERT gene promoter in a single case of uveal melanoma
- M Dono
- , G Angelini
- & U Pfeffer
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Molecular Diagnostics
| Open AccessTriple negative breast carcinoma EGFR amplification is not associated with EGFR, Kras or ALK mutations
- V Secq
- , J Villeret
- & C Charpin
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Letter to the Editor
| Open AccessIntra-patient heterogeneity of BRAF mutation status: fact or fiction?
- A M Menzies
- , J S Wilmott
- & R A Scolyer
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Short Communication
| Open AccessGermline CDH1 mutations in bilateral lobular carcinoma in situ
- C Petridis
- , I Shinomiya
- & E J Sawyer
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Genetics and Genomics
| Open AccessHBx mutants differentially affect the activation of hypoxia-inducible factor-1α in hepatocellular carcinoma
- L-p Liu
- , B-g Hu
- & P B S Lai
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Genetics and Genomics
| Open AccessIncidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers: results from a follow-up study
- C M Phelan
- , J Iqbal
- & Tomasz Huzarski
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Molecular Diagnostics
| Open AccessMutation landscape in melanoma patients clinical implications of heterogeneity of BRAF mutations
- L Heinzerling
- , M Baiter
- & R Schneider-Stock
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Genetics and Genomics
| Open AccessDICER1 hotspot mutations in non-epithelial gonadal tumours
- L Witkowski
- , J Mattina
- & W D Foulkes
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Molecular Diagnostics
| Open AccessEGFR mutational status in a large series of Caucasian European NSCLC patients: data from daily practice
- S Gahr
- , R Stoehr
- & W Dietmaier
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Genetics and Genomics
| Open AccessLoss of PTEN expression is an independent predictor of favourable survival in endometrial carcinomas
- A Akiyama-Abe
- , T Minaguchi
- & H Yoshikawa
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Genetics and Genomics
| Open AccessDeleterious BRCA1/2 mutation is an independent risk factor for carboplatin hypersensitivity reactions
- D H Moon
- , J-M Lee
- & E C Kohn
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Clinical Study
| Open AccessKIT, NRAS and BRAF mutations in sinonasal mucosal melanoma: a study of 56 cases
- A Zebary
- , M Jangard
- & J Hansson
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Short Communication
| Open AccessTERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours
- K G Griewank
- , R Murali
- & M Zeschnigk
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Short Communication
| Open AccessBCR-ABL1 kinase domain mutations may persist at very low levels for many years and lead to subsequent TKI resistance
- W T Parker
- , A L Yeoman
- & S Branford
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Molecular Diagnostics
| Open AccessTumour morphology predicts PALB2 germline mutation status
- Z L Teo
- , E Provenzano
- & M C Southey
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Short Communication
| Open AccessPatient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11
- A E Koopmans
- , J Vaarwater
- & A de Klein
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Short Communication
| Open AccessOutcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab
- M Cizkova
- , M-E Dujaric
- & I Bieche
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Genetics and Genomics
| Open AccessRare BRAF mutations in melanoma patients: implications for molecular testing in clinical practice
- L Heinzerling
- , S Kühnapfel
- & R Schneider-Stock
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Genetics and Genomics
| Open AccessTriple-negative breast cancer: BRCAness and concordance of clinical features with BRCA1-mutation carriers
- E H Lips
- , L Mulder
- & P M Nederlof
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Genetics and Genomics
| Open AccessKRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markers
- A I Phipps
- , D D Buchanan
- & P A Newcomb