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Open Access
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Article
| Open AccessMutant TP53 interacts with BCAR1 to contribute to cancer cell invasion
- Alvin Kunyao Guo
- , Yoko Itahana
- & Koji Itahana
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Brief Communication
| Open AccessThe mutational landscape of melanoma brain metastases presenting as the first visceral site of recurrence
- Roy Rabbie
- , Peter Ferguson
- & David J. Adams
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Brief Communication
| Open AccessNme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma
- Nidhi Pamidimukkala
- , Gemma S. Puts
- & David M. Kaetzel
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Article
| Open AccessSuppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5
- Eric D. Young
- , Sharon J. Manley
- & Danny R. Welch
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Correspondence
| Open AccessComment on: the myth of pulmonary metastasectomy
- Matthieu Zellweger
- & Michel Gonzalez
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Article
| Open AccessOXPHOS-dependent metabolic reprogramming prompts metastatic potential of breast cancer cells under osteogenic differentiation
This manuscript provides a simplified overview of the involvement of mitochondrial activity and OXPHOS in the metastasis of breast cancer with calcification. We propose that massive accumulation of calcified granules due to breast cancer necrosis or deposition of spontaneous secretions around the glands lead to reprogramming of tumour metabolism, particularly enhancement of mitochondrial metabolism. Upregulation of the OXPHOS complex and subsequent activation of TGFβ-SMAD and MAPK (e.g., JNK, ERK, P38) signalling pathways facilitate the EMT process of breast cancer cells. Interestingly, the OXPHOS inhibitor rotenone could block the EMT process due to cell calcification.
- Yangling Hu
- , Weimin Xu
- & Weiguo Chen
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Article
| Open AccessEGFR as a stable marker of prostate cancer dissemination to bones
- Paulina Nastały
- , Sara Stoupiec
- & Natalia Bednarz-Knoll
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Article
| Open AccessGalectin-3 favours tumour metastasis via the activation of β-catenin signalling in hepatocellular carcinoma
- Mengjia Song
- , Qiuzhong Pan
- & Jian-Chuan Xia
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Editorial
| Open AccessMiliary breast cancer brain metastasis: a rare and aggressive form of central nervous system metastasis
- Matthew N. Mills
- & Kamran A. Ahmed
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Article
| Open AccessCentral nervous system miliary metastasis in breast cancer: a case series analysis and proposed identification criteria of a rare metastasis subtype
- Sami I. Bashour
- , Nuhad K. Ibrahim
- & Gregory N. Fuller
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Article
| Open AccessSuppression of G6PD induces the expression and bisecting GlcNAc-branched N-glycosylation of E-Cadherin to block epithelial-mesenchymal transition and lymphatic metastasis
- Yifei Wang
- , Qingxiang Li
- & Chuanbin Guo
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Review Article
| Open AccessIntratumoural immunotherapies for unresectable and metastatic melanoma: current status and future perspectives
- Mark R. Middleton
- , Christoph Hoeller
- & Axel Hauschild
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Article |
IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma
- Chun-fen Mo
- , Jun Li
- & Qiang Zou
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Article
| Open AccessMicroRNA-17-5p regulates EMT by targeting vimentin in colorectal cancer
- Tae Won Kim
- , Yeo Song Lee
- & Yong Beom Cho
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Article
| Open AccessIntra-arterial hepatic beads loaded with irinotecan (DEBIRI) with mFOLFOX6 in unresectable liver metastases from colorectal cancer: a Phase 2 study
- Simon Pernot
- , Olivier Pellerin
- & Julien Taieb
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Article
| Open AccessEffects of effective stereotactic radiosurgery for brain metastases on the adjacent brain parenchyma
- Sabine Wagner
- , Heinrich Lanfermann
- & Hubert Gufler
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Article
| Open AccessRegulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells
- Xin Wang
- , Danxiu Li
- & Yuanyuan Lu
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Article
| Open AccessNon-inferiority randomised phase 3 trial comparing two radiation schedules (single vs. five fractions) in malignant spinal cord compression
- Pierre G. Thirion
- , Mary T. Dunne
- & Michael Moriarty
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Article
| Open AccessDevelopment of prediction models for lymph node metastasis in endometrioid endometrial carcinoma
- Hege F. Berg
- , Zhenlin Ju
- & Henrica M. J. Werner
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Article
| Open AccessTumour-derived extracellular vesicles in blood of metastatic cancer patients associate with overall survival
- Afroditi Nanou
- , M. Craig Miller
- & Leon W. M. M. Terstappen
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Article
| Open AccessMFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming
- Ze Zhang
- , Tian-En Li
- & Lun-Xiu Qin
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Article
| Open AccessImpact of breast cancer molecular subtypes on the incidence, kinetics and prognosis of central nervous system metastases in a large multicentre real-life cohort
- Amélie Darlix
- , Guillaume Louvel
- & Thomas Bachelot
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Article
| Open AccessLong-term survival in patients with metastatic head and neck squamous cell carcinoma treated with metastasis-directed therapy
- Thomas H. Beckham
- , Jonathan E. Leeman
- & C. Jillian Tsai
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Article
| Open AccessYY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways
- Qun Chen
- , Chuang Yang
- & Kui-Rong Jiang
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Article
| Open AccessMicroRNA-222 reprogrammed cancer-associated fibroblasts enhance growth and metastasis of breast cancer
- Annesha Chatterjee
- , Samir Jana
- & Arindam Bhattacharyya
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Editorial |
Solid cancer: the new tumour spread endpoint opens novel opportunities
- Michael Fernandes
- , Daniel Rosel
- & Jan Brábek
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Article
| Open AccessNotch2 pathway mediates breast cancer cellular dormancy and mobilisation in bone and contributes to haematopoietic stem cell mimicry
- Mattia Capulli
- , Dayana Hristova
- & Anna Teti
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Review Article
| Open AccessThe role of mouse tumour models in the discovery and development of anticancer drugs
- Christopher R. Ireson
- , Mo S. Alavijeh
- & Hazel J. Jones
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Article
| Open AccessLGR5 expression predicts peritoneal recurrence after curative resection of primary colon cancer
- Hiroshi Nagata
- , Soichiro Ishihara
- & Hiroaki Nozawa
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Brief Communication
| Open AccessRevisiting immune escape in colorectal cancer in the era of immunotherapy
- Marieke Erica Ijsselsteijn
- , Florent Petitprez
- & Noel Filipe da Cunha Carvalho de Miranda
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Article
| Open AccessPrognostic value of serum alkaline phosphatase in spinal metastatic disease
- Aditya V. Karhade
- , Quirina C. B. S. Thio
- & Joseph H. Schwab
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Article
| Open AccessHAI-2 as a novel inhibitor of plasmin represses lung cancer cell invasion and metastasis
- Shang-Ru Wu
- , Chia-Hao Lin
- & Ming-Shyue Lee
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Article
| Open AccessTumour cell blebbing and extracellular vesicle shedding: key role of matrikines and ribosomal protein SA
- Bertrand Brassart
- , Jordan Da Silva
- & Sylvie Brassart-Pasco
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Article
| Open AccessCirculating tumour cells and their association with bone metastases in patients with neuroendocrine tumours
- Francesca M. Rizzo
- , Clare Vesely
- & Tim Meyer
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Article
| Open AccessPre- and post-operative anti-PD-L1 plus anti-angiogenic therapies in mouse breast or renal cancer models of micro- or macro-metastatic disease
- Florence T. H. Wu
- , Ping Xu
- & Robert S. Kerbel
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Article
| Open AccessNorth American population-based validation of the National Comprehensive Cancer Network Practice Guideline Recommendations for locoregional lymph node and bone imaging in prostate cancer patients
- Felix Preisser
- , Elio Mazzone
- & Pierre I. Karakiewicz
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Article
| Open AccessAn IL13Rα2 peptide exhibits therapeutic activity against metastatic colorectal cancer
- Rubén A. Bartolomé
- , Marta Jaén
- & J. Ignacio Casal
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Article
| Open AccessSafety, pharmacokinetics, and preliminary efficacy of E6201 in patients with advanced solid tumours, including melanoma: results of a phase 1 study
- Raoul Tibes
- , Mitesh J. Borad
- & Daniel D. Von Hoff
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Article
| Open AccessRIPK4 promotes bladder urothelial carcinoma cell aggressiveness by upregulating VEGF-A through the NF-κB pathway
- Jian-Ye Liu
- , Qing-Hai Zeng
- & Ke Cao
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Article
| Open AccessEndothelial Akt1 loss promotes prostate cancer metastasis via β-catenin-regulated tight-junction protein turnover
- Fei Gao
- , Abdulrahman Alwhaibi
- & Payaningal R. Somanath
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Article
| Open AccessChemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis
- Jing-Jing Li
- , Hong-Kun Yin
- & Dong Xie
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Molecular Diagnostics
| Open AccessReduced mannosidase MAN1A1 expression leads to aberrant N-glycosylation and impaired survival in breast cancer
- Karen Legler
- , Ricarda Rosprim
- & Leticia Oliveira-Ferrer
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Translational Therapeutics
| Open AccessHER2 expression patterns in paired primary and metastatic endometrial cancer lesions
- Mari Kyllesø Halle
- , Ingvild Løberg Tangen
- & Camilla Krakstad
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Molecular Diagnostics
| Open AccessSox5 contributes to prostate cancer metastasis and is a master regulator of TGF-β-induced epithelial mesenchymal transition through controlling Twist1 expression
- Jieping Hu
- , Jing Tian
- & Zhiqun Shang
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Mini Review
| Open AccessTAMeless traitors: macrophages in cancer progression and metastasis
- Shweta Aras
- & M Raza Zaidi
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Clinical Study
| Open AccessEffect of a mentor-based, supportive-expressive program, Be Resilient to Breast Cancer, on survival in metastatic breast cancer: a randomised, controlled intervention trial
- Zeng Jie Ye
- , Hong Zhong Qiu
- & Jing Jing Zhao
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Molecular Diagnostics
| Open AccessMDM2 promotes epithelial–mesenchymal transition and metastasis of ovarian cancer SKOV3 cells
- Ying Chen
- , Dan-Dan Wang
- & Bo Yang
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Molecular Diagnostics
| Open AccessOne-step nucleic acid amplification assay is an accurate technique for sentinel lymph node biopsy of breast cancer patients: a meta-analysis
- Fang Shi
- , Qian Zhang
- & Xin Liu
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Molecular Diagnostics
| Open AccessTumour mutation status and sites of metastasis in patients with cutaneous melanoma
- Nikki R Adler
- , Rory Wolfe
- & Victoria J Mar