Immunological disorders articles within Nature

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  • Letter |

    Interleukin-1β-induced disruption to endothelial stability and vascular permeability in a human in vitro model is shown to be independent of downstream nuclear factor-κB activation, relying instead on a MYD88–ARNO–ARF6 signalling cascade; inhibiting proteins involved in this pathway is shown to improve outcomes in animal models of inflammatory disease.

    • Weiquan Zhu
    • , Nyall R. London
    •  & Dean Y. Li

  • Comment |

    Joel V. Weinstock explains why several clinical trials are deliberately infecting people with helminths to treat autoimmune diseases.

    • Joel V. Weinstock

  • Letter |

    A meta-analysis of previous genome-wide association studies of Crohn’s disease and ulcerative colitis, the two most common forms of inflammatory bowel disease, with a combined total of more than 75,000 cases and controls, finds that most loci contribute to both phenotypes and other immune-mediated disorders.

    • Luke Jostins
    • , Stephan Ripke
    •  & Judy H Cho

  • Article |

    A novel neutralizing antibody from a healthy HIV-1-infected donor that is specific for the membrane proximal region of gp41 is reported; the antibody has high potency and breadth, is not autoreactive and does not bind phospholipids.

    • Jinghe Huang
    • , Gilad Ofek
    •  & Mark Connors

  • News & Views |

    In multiple sclerosis, the body's own immune cells attack the brain and spinal cord. But how they get there from peripheral tissues has been a mystery. Surprisingly, the lungs might be a key transit point. See Letter p.675

    • Richard M. Ransohoff

  • Letter |

    A Lewis rat model of experimental autoimmune encephalomyelitis is used to show that on their way to the CNS, encephalitogenic T-cell blasts are temporarily resident in the lung, where they reprogram their gene-expression profile and functional properties to enable them to transgress the blood–brain barrier into the CNS.

    • Francesca Odoardi
    • , Christopher Sie
    •  & Alexander Flügel

  • News & Views |

    Dietary lack of a single amino acid impairs intestinal immunity in mice, altering the guts microbial community and leaving it vulnerable to damage. The finding helps to explain how malnutrition favours gut inflammation. See Letter p.477

    • Ana Izcue
    •  & Fiona Powrie

  • Comment |

    Steven G. Deeks and Françoise Barré-Sinoussi present an international research agenda to seek out a cure for AIDS.

    • Steven G. Deeks
    •  & Françoise Barré-Sinoussi

  • News & Views |

    Western-style diets could be contributing to the rapid increase in inflammatory bowel disease. New research suggests that dietary fat can alter bile composition and so favour the growth of pro-inflammatory gut microbes. See Letter p.104

    • Peter J. Turnbaugh

  • Article |

    Myocardial infarction accelerates atherosclerosis through activation of the sympathetic nervous system, and the consequent release of haematopoietic stem and progenitor cells.

    • Partha Dutta
    • , Gabriel Courties
    •  & Matthias Nahrendorf

  • Comment |

    China's discomfort over discussing sex, and especially homosexuality, is a major problem when it comes to HIV, says a consortium of researchers in China.

    • Hong Shang
    • , Junjie Xu
    •  & Linqi Zhang

  • Outlook |

    Recent research suggests that the fight against type 1 diabetes is focusing too narrowly on the adaptive immune system, says Carla Greenbaum.

    • Carla Greenbaum

  • Outlook |

    In type 1 diabetes, the immune system goes haywire and depletes insulin-producing cells. Drugs that interfere with this process could one day reverse the disease's course.

    • Sarah DeWeerdt

  • News & Views Forum |

    An article suggesting that allergic responses may not be an accident of an off-target immune system, but rather a deliberate defence against potential harm, provokes the question of whether our understanding of allergy needs an overhaul. Immunologists provide their opinions. See Perspective p.465

    • David Artis
    • , Rick M. Maizels
    •  & Fred D. Finkelman

  • Perspective |

    A review of allergic host defences argues that allergic immunity has an important role in host defence against noxious environmental substances.

    • Noah W. Palm
    • , Rachel K. Rosenstein
    •  & Ruslan Medzhitov

  • Outlook |

    Population and genetic studies are confirming the link between multiple sclerosis and vitamin D, says Richard Ransohoff.

    • Richard M. Ransohoff

  • Outlook |

    Most new treatments for multiple sclerosis are for patients with the relapsing–remitting form of the disease. Those with the more advanced, progressive type are being left behind.

    • Courtney Humphries

  • Outlook |

    Researchers have plenty of theories about what might cause multiple sclerosis. But for now, the factor that triggers the disease remains elusive.

    • Lauren Gravitz

  • Outlook |

    More than 100 variations in the genome have been linked to multiple sclerosis. Researchers are now trying to find the overlap with other auto-immune conditions, and understand how environmental factors interact with genes to trigger disease.

    • Virginia Hughes

  • Outlook |

    A slew of new data suggests that it is time to rethink and reclassify autoimmune disease, says David A. Hafler.

    • David A. Hafler

  • Outlook |

    Worms? Stents? Bee stings? Patients with multiple sclerosis who exhaust conventional therapies are turning in desperation to unproven approaches.

    • Jennifer Berglund

  • Outlook |

    Researchers are still a long way from using stem cells to halt the decline caused by multiple sclerosis and to restore patients' health. But they are following some promising trails.

    • Michael Eisenstein

  • Outlook |

    For decades, drugs have barely managed to slow the progression of multiple sclerosis. Therapies are now emerging that may even help to reverse the disease — but are they worth the risk?

    • Duncan Graham-Rowe

  • Letter |

    Thymus-derived regulatory T cells are activated by recognition of peripheral self antigen, persist in the target tissue on cessation of antigen exposure, and respond to re-exposure to self antigen with enhanced functional activity.

    • Michael D. Rosenblum
    • , Iris K. Gratz
    •  & Abul K. Abbas

  • Outlook |

    A plethora of therapies can keep the symptoms of allergy under control, but they can't cure. New research aims to prevent allergies from developing in the first place.

    • Lauren Gravitz

  • Outlook |

    Stephen Holgate argues for a return to more human-centred studies of allergy and asthma.

    • Stephen Holgate

  • Outlook |

    They come not single spies, but in battalions. The latest research helps explain why an individual may experience the 'atopic march' from one allergic disorder to another.

    • Paige Brown

  • Outlook |

    Clinical trials are testing how careful exposure could protect people with potentially lethal allergies to everyday fare.

    • Rebecca Kessler

  • Outlook |

    Asthma was once thought to be a uniform disease triggered by one type of immune cell. Researchers are now revealing the complexity of the condition and hope to hasten new drugs for forms unresponsive to steroids.

    • Amy Maxmen

  • Outlook |

    Rare gene variants could be key to unlocking the underlying genetics of allergy, now that whole genome sequencing and other technologies have sharpened the focus of epidemiology.

    • Erica Westly

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