Autoimmune diseases articles within Nature

Featured

  • Article
    | Open Access

    Autoreactive T cells that target myelin antigens in the peripheral nerves are present in patients with the demyelinating form of Guillain–Barré syndrome, and these T cells are likely to contribute to disease pathophysiology.

    • L. Súkeníková
    • , A. Mallone
    •  & D. Latorre

  • Article |

    cis-RNA editing quantitative trait loci, which are associated with immunogenic double-stranded RNAs, underlie genome-wide association study variants in common autoimmune and inflammatory diseases.

    • Qin Li
    • , Michael J. Gloudemans
    •  & Jin Billy Li

  • Article |

    An HLA- and gluten-dependent mouse model of coeliac disease with villous atrophy provides evidence for the cooperative role of IL-15 and gluten-specific CD4+ T cells in licensing the full activation of cytotoxic T cells that are necessary for inducing epithelial damage.

    • Valérie Abadie
    • , Sangman M. Kim
    •  & Bana Jabri

  • Letter
    | Open Access

    An analysis of more than 10,000 metagenomes from the TEDDY study provides a detailed functional profile of the gut microbiome in relation to islet autoimmunity, and supports the protective effects of short-chain fatty acids in early-onset type 1 diabetes.

    • Tommi Vatanen
    • , Eric A. Franzosa
    •  & Ramnik J. Xavier

  • Article |

    High salt intake changed the gut microbiome and increased TH17 cell numbers in mice, and reduced intestinal survival of Lactobacillus species, increased the number of TH17 cells and increased blood pressure in humans.

    • Nicola Wilck
    • , Mariana G. Matus
    •  & Dominik N. Müller

  • Article |

    Nanoparticles coated with autoantigenic peptides bound to MHC class II molecules suppress established autoimmune disease by inducing antigen-specific TR1-like regulatory T cells in mouse and humanized mouse models.

    • Xavier Clemente-Casares
    • , Jesus Blanco
    •  & Pere Santamaria

  • Letter |

    A study of the super-enhancer landscape in three mouse T-helper lymphocyte subsets identifies nodes that have key roles in cell identity, with the locus encoding Bach2, a key negative regulator of effector differentiation, emerging as the most prominent T-cell super-enhancer.

    • Golnaz Vahedi
    • , Yuka Kanno
    •  & John J. O’Shea

  • Letter |

    Failure of integrin-mediated cell-matrix attachment is sufficient to initiate dermal fibrosis and autoimmunity in mouse models of scleroderma; integrin-modulating therapies prevent the recruitment and activation of plasmacytoid dendritic cells that appear central to immunological dysregulation and maintenance of the pro-fibrotic synthetic programme.

    • Elizabeth E. Gerber
    • , Elena M. Gallo
    •  & Harry C. Dietz

  • Letter |

    A search for variants in coding exons of 25 genome-wide association study risk genes in a large cohort of autoimmune patients finds that rare coding-region variants at known loci have a negligible role in common autoimmune disease susceptibility, arguing against the previously proposed rare-variant synthetic genome-wide association hypothesis.

    • Karen A. Hunt
    • , Vanisha Mistry
    •  & David A. van Heel

  • Outlook |

    Science is finally getting to grips with this enigmatic autoimmune disease.

    • James Mitchell Crow

  • Outlook |

    • Michelle Grayson

  • Outlook |

    The latest drugs hold fantastic promise for people with severe psoriasis. But where are the treatment options for the far larger number with less serious cases?

    • James Mitchell Crow

  • Outlook |

    As the link between stress and psoriasis flare-ups becomes clearer, it seems the most vulnerable patients require a new type of treatment.

    • Sarah DeWeerdt

  • Outlook |

    Psoriasis can have a profound impact on patients' emotional and social lives. Christopher Griffiths, a dermatologist at the University of Manchester in the United Kingdom, discusses the disease's psychological fallout and its links with stress.

    • Christopher Griffiths

  • Outlook |

    Severe psoriasis carries cardiovascular risks. Dermatologists should consider more than just patients' outer layers, argues Henning Boehncke.

    • Wolf-Henning Boehncke

  • Outlook |

    Recent discoveries are redefining the role of the immune system in psoriasis, and may help to unravel the mystery of the disease's origins.

    • Ken Garber

  • Outlook |

    Our skin is home to thousands of species of bacteria — and when these microscopic societies are disrupted, skin infections can arise.

    • Bijal Trivedi

  • Outlook |

    No mere passive barrier, the skin is being revealed to be an active part of the immune system. Researchers are now starting to understand its role in driving psoriasis.

    • Claire Ainsworth

  • Comment |

    Joel V. Weinstock explains why several clinical trials are deliberately infecting people with helminths to treat autoimmune diseases.

    • Joel V. Weinstock

  • News & Views |

    In multiple sclerosis, the body's own immune cells attack the brain and spinal cord. But how they get there from peripheral tissues has been a mystery. Surprisingly, the lungs might be a key transit point. See Letter p.675

    • Richard M. Ransohoff

  • Letter |

    A Lewis rat model of experimental autoimmune encephalomyelitis is used to show that on their way to the CNS, encephalitogenic T-cell blasts are temporarily resident in the lung, where they reprogram their gene-expression profile and functional properties to enable them to transgress the blood–brain barrier into the CNS.

    • Francesca Odoardi
    • , Christopher Sie
    •  & Alexander Flügel

  • Outlook |

    Recent research suggests that the fight against type 1 diabetes is focusing too narrowly on the adaptive immune system, says Carla Greenbaum.

    • Carla Greenbaum

  • Outlook |

    In type 1 diabetes, the immune system goes haywire and depletes insulin-producing cells. Drugs that interfere with this process could one day reverse the disease's course.

    • Sarah DeWeerdt

  • Outlook |

    Population and genetic studies are confirming the link between multiple sclerosis and vitamin D, says Richard Ransohoff.

    • Richard M. Ransohoff

  • Outlook |

    Most new treatments for multiple sclerosis are for patients with the relapsing–remitting form of the disease. Those with the more advanced, progressive type are being left behind.

    • Courtney Humphries

  • Outlook |

    Researchers have plenty of theories about what might cause multiple sclerosis. But for now, the factor that triggers the disease remains elusive.

    • Lauren Gravitz

  • Outlook |

    More than 100 variations in the genome have been linked to multiple sclerosis. Researchers are now trying to find the overlap with other auto-immune conditions, and understand how environmental factors interact with genes to trigger disease.

    • Virginia Hughes

  • Outlook |

    A slew of new data suggests that it is time to rethink and reclassify autoimmune disease, says David A. Hafler.

    • David A. Hafler

  • Outlook |

    Worms? Stents? Bee stings? Patients with multiple sclerosis who exhaust conventional therapies are turning in desperation to unproven approaches.

    • Jennifer Berglund

  • Outlook |

    Researchers are still a long way from using stem cells to halt the decline caused by multiple sclerosis and to restore patients' health. But they are following some promising trails.

    • Michael Eisenstein

  • Outlook |

    For decades, drugs have barely managed to slow the progression of multiple sclerosis. Therapies are now emerging that may even help to reverse the disease — but are they worth the risk?

    • Duncan Graham-Rowe

  • Letter |

    Thymus-derived regulatory T cells are activated by recognition of peripheral self antigen, persist in the target tissue on cessation of antigen exposure, and respond to re-exposure to self antigen with enhanced functional activity.

    • Michael D. Rosenblum
    • , Iris K. Gratz
    •  & Abul K. Abbas

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