Featured
-
-
Article |
Antigenicity and receptor affinity of SARS-CoV-2 BA.2.86 spike
A severe acute respiratory syndrome coronavirus 2 Omicron subvariant, BA.2.86, was found to be no more resistant to human sera than the currently dominant XBB.1.5 and EG.5.1, but it had a remarkably higher receptor affinity.
- Qian Wang
- , Yicheng Guo
- & David D. Ho
-
Article
| Open Access
Learning from prepandemic data to forecast viral escape
EVEscape, a flexible framework using deep learning and biophysical structural information, enables early identification of concerning mutations in viruses with pandemic potential, facilitating the development of vaccines and therapeutics.
- Nicole N. Thadani
- , Sarah Gurev
- & Debora S. Marks
-
Article
| Open Access
TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6
The well-characterized HIV restriction factor TRIM5α also restricts orthopoxviruses and is countered by the viral protein C6 and the proviral activity of CypA, which in turn is antagonized by CsA and derivatives alisporivir and NIM811.
- Yiqi Zhao
- , Yongxu Lu
- & Geoffrey L. Smith
-
Article |
Y chromosome loss in cancer drives growth by evasion of adaptive immunity
Loss of the Y chromosome in tumour cells is associated with a poor prognosis for patients with bladder cancer by causing local T cell exhaustion, which also increases the response to immune checkpoint blockade therapy.
- Hany A. Abdel-Hafiz
- , Johanna M. Schafer
- & Dan Theodorescu
-
Article
| Open Access
Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution
Convergent mutations in hotspots of the SARS-CoV-2 Omicron receptor-binding domain can cause immune evasion and maintain sufficient ACE2-binding capability.
- Yunlong Cao
- , Fanchong Jian
- & Xiaoliang Sunney Xie
-
Article |
Pregnancy enables antibody protection against intracellular infection
Pregnancy-induced post-translational antibody modification enables protection against the prototypical intracellular pathogen Listeria monocytogenes.
- John J. Erickson
- , Stephanie Archer-Hartmann
- & Sing Sing Way
-
Article |
Landscape of helper and regulatory antitumour CD4+ T cells in melanoma
A survey of the CD4+ T cells in human melanomas indicates that immune evasion is mediated through direct stimulation of neoantigen-specific tumour-reactive regulatory T cells by HLA class II-positive melanoma cells.
- Giacomo Oliveira
- , Kari Stromhaug
- & Catherine J. Wu
-
Article |
Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence
Studies in a mouse model of neurolisteriosis show that the effector protein InlB produced by Listeria monocytogenes protects infected monocytes in the host from T cell-mediated cell death, and thereby increases bacterial neuroinvasion, persistence and transmission.
- Claire Maudet
- , Marouane Kheloufi
- & Marc Lecuit
-
Article
| Open Access
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
The spike protein of the Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 than Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic and vaccine-elicited neutralizing antibodies.
- Bo Meng
- , Adam Abdullahi
- & Ravindra K. Gupta
-
Article |
High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape
A complex range of mutations within the SARS-CoV-2 spike protein is needed to escape polyclonal plasma neutralizing antibodies, and plasma from individuals who were first infected then vaccinated display the greatest resilience to escape mutations.
- Fabian Schmidt
- , Yiska Weisblum
- & Paul D. Bieniasz
-
Article |
SARS-CoV-2 evolution during treatment of chronic infection
Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.
- Steven A. Kemp
- , Dami A. Collier
- & Ravindra K. Gupta
-
Article |
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Genome-wide CRISPR screens in mouse cancer cell lines are used to identify a core, conserved set of genes and pathways that govern how cancer cells evade killing by cytotoxic T lymphocytes.
- Keith A. Lawson
- , Cristovão M. Sousa
- & Jason Moffat
-
Letter |
FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing
HIV-1 uses the host protein FTSJ3 to methylate its own genome, thereby evading detection by the innate immune system.
- Mathieu Ringeard
- , Virginie Marchand
- & Yamina Bennasser
-
Letter |
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells
PD-1 undergoes internalization, FBXO38-mediated ubiquitination and proteasome degradation in activated T cells, and inhibition of this pathway dampens anti-tumour immunity of T cells.
- Xiangbo Meng
- , Xiwei Liu
- & Chenqi Xu
-
Letter
| Open Access
Genome organization and DNA accessibility control antigenic variation in trypanosomes
Long-read sequencing allows the assembly of antigen-gene arrays in Trypanosoma brucei and, coupled with deletion experiments, demonstrates that histone variants act as a molecular link between genome architecture, chromatin conformation and antigen variation.
- Laura S. M. Müller
- , Raúl O. Cosentino
- & T. Nicolai Siegel
-
Article |
A homing system targets therapeutic T cells to brain cancer
Therapeutic T cells bearing ligands engineered to optimize adhesion and transmigration through the blood–brain barrier can be targeted to brain tumours.
- Heba Samaha
- , Antonella Pignata
- & Nabil Ahmed
-
Letter |
Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors
Proteins expressed on the surfaces of erythrocytes infected with Plasmodium falciparum help the parasite to evade the host immune system by acting as ligands for immune inhibitory receptors and thereby downregulating the immune response.
- Fumiji Saito
- , Kouyuki Hirayasu
- & Hisashi Arase
-
Letter |
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity
CMTM6 maintains PD-L1 at the plasma membrane by inhibiting its lysosome-mediated degradation and promoting its recycling.
- Marian L. Burr
- , Christina E. Sparbier
- & Mark A. Dawson
-
Letter |
Neoantigen landscape dynamics during human melanoma–T cell interactions
Analyses of tumour samples and tumour-infiltrating lymphocytes from two patients with melanoma who were treated with adoptive T-cell therapy provide evidence for tumour escape by loss and downregulation of immunogenic antigens.
- Els M. E. Verdegaal
- , Noel F. C. C. de Miranda
- & Sjoerd H. van der Burg
-
Letter |
A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter
The cryo-electron microscopy structure of human TAP transporter, a peptide transporter central to MHC class I antigen presentation and cellular immunity, in complex with the herpes simplex virus protein ICP47.
- Michael L. Oldham
- , Richard K. Hite
- & Jue Chen
-
Letter |
Severe malaria is associated with parasite binding to endothelial protein C receptor
Endothelial protein C receptor is shown to be the receptor for Plasmodium falciparum erythrocyte membrane protein 1 variants associated with severe malaria.
- Louise Turner
- , Thomas Lavstsen
- & Thor G. Theander
-
Letter |
HIV-1 adaptation to NK-cell-mediated immune pressure
- Galit Alter
- , David Heckerman
- & Marcus Altfeld
A host–microbiota interactome reveals extensive transkingdom connectivity