Health sciences articles within Nature Reviews Clinical Oncology

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  • News & Views |

    Patients with stage III non-small-cell lung cancer (NSCLC) comprise a heterogeneous population; the role of surgical resection in this setting has been controversial. Albain and colleagues recently demonstrated that trimodality therapy with lobectomy had clinical benefit for patients with pathologic nodal N2 stage III NSCLC. We discuss the trial and its implications for future lung cancer therapy.

    • Anne S. Tsao
    • , Jack A. Roth
    •  & Roy S. Herbst

  • News & Views |

    Motzer and colleagues present updated results from a multicenter, phase III trial of sunitinib versus interferon-α as first-line treatment for patients with metastatic renal-cell carcinoma. The observed improvement in overall survival for patients treated with sunitinib further establishes this agent as the reference standard for first-line treatment of good-risk and intermediate-risk patients with metastatic renal cancer.

    • Jason E. Faris
    •  & M. Dror Michaelson

  • Case Study |

    This Case Study describes a patient with breast cancer who was treated with capecitabine and experienced a severe adverse event when treated with brivudin for a herpes infection. The authors discuss drug–drug interactions and management of the associated toxic effects.

    • José M. Baena-Cañada
    • , María J. Martínez
    •  & Pedro Muriel-Cueto

  • Opinion |

    When cancer survival statistics worsen over time a common assumption is that care must have deteriorated. A variety of reasons cause cancer survival to drop, including improved diagnosis of premalignant lesions, deleterious changes in the distribution of prognostic factors, and changes in the distribution of sociodemographic characteristics. In this article, the pitfalls of comparing published population-based survival data from different time periods or populations are discussed.

    • Esther de Vries
    • , Henrike E. Karim-Kos
    •  & Jan Willem W. Coebergh

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