Review Article |
Featured
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Review Article |
Global burden of gastric cancer: epidemiological trends, risk factors, screening and prevention
Globally, gastric cancer is a common and highly fatal cancer with two anatomical subtypes, non-cardia and cardia gastric cancer. Helicobacter pylori causes almost 90% of distal gastric cancers worldwide. The authors of this Review summarize the current epidemiology of gastric cancer and the evidence and implications of primary and secondary prevention efforts.
- Aaron P. Thrift
- , Theresa Nguyen Wenker
- & Hashem B. El-Serag
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Perspective |
Rising incidence of early-onset colorectal cancer — a call to action
The incidence of early-onset colorectal cancer (CRC) is increasing worldwide for reasons that are currently unclear. Herein, the authors review the current epidemiological, clinical, pathological and molecular understanding of early-onset CRC that occurs in patients ≥50 years of age, drawing contrasts with later-onset CRC. They also discuss future research strategies for improved understanding, prevention, early detection and clinical management of early-onset CRC.
- Naohiko Akimoto
- , Tomotaka Ugai
- & Shuji Ogino
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News & Views |
Microbes as biomarkers and targets in pancreatic cancer
The presence and prognostic relevance of the intratumoural microbiota in pancreatic cancer, and the roles of intratumoural bacteria in oncogenesis and therapeutic response are beginning to be elucidated. The feasibility of characterizing intratumoural microbial communities from paraffin-embedded tissues has now been validated, providing greater opportunities for retrospective research. Prospective studies are also needed to test the efficacy of rational approaches combining microbial modulation with chemotherapy and/or immunotherapy.
- Joshua C. Leinwand
- & George Miller
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