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| Open AccessDevelopment of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide
- Maria Giulia Di Giglio
- , Markus Muttenthaler
- & Christian W. Gruber
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| Open AccessUnraveling the cytotoxicity and metabolic pathways of binary natural deep eutectic solvent systems
- Yves Paul Mbous
- , Maan Hayyan
- & Mohd Ali Hashim
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| Open AccessSuccinate ester derivative of δ-tocopherol enhances the protective effects against 60Co γ-ray-induced hematopoietic injury through granulocyte colony-stimulating factor induction in mice
- Zhong-Tang Li
- , Li-Mei Wang
- & Yu-Wen Cong
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| Open AccessCaffeic Acid Cyclohexylamide Rescues Lethal Inflammation in Septic Mice through Inhibition of IκB Kinase in Innate Immune Process
- Jun Hyeon Choi
- , Sun Hong Park
- & Youngsoo Kim
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| Open AccessDOE Optimization of Nano-based Carrier of Pregabalin as Hydrogel: New Therapeutic & Chemometric Approaches for Controlled Drug Delivery Systems
- Mona G. Arafa
- & Bassam M. Ayoub
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| Open AccessDiscovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling
- Ralph Adams
- , Rebecca J. Burnley
- & Anna Ettorre
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| Open AccessAqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells
- Yu-Huei Liu
- , Yui-Ping Weng
- & Jung-Yaw Lin
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| Open AccessEpigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains
- Manuel Hora
- , Martin Carballo-Pacheco
- & Bernd Reif
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| Open AccessIdentification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro
- Wei Yi
- , Jingjing Shi
- & H. Eric Xu
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| Open AccessProtective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway
- Jialin Duan
- , Yue Guan
- & Aidong Wen
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| Open AccessComputational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping
- Xiaofeng Liu
- , Richard D. Taylor
- & Terry Baker
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| Open AccessIntracellular degradation of functionalized carbon nanotube/iron oxide hybrids is modulated by iron via Nrf2 pathway
- Dan Elgrabli
- , Walid Dachraoui
- & Florence Gazeau
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| Open AccessMelatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling
- Liming Yu
- , Bing Gong
- & Huishan Wang
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| Open AccessThe green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells
- Clementina Sansone
- , Christian Galasso
- & Adrianna Ianora
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Article
| Open AccessDecoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis
- Sabrina Cipriani
- , Adriana Carino
- & Stefano Fiorucci
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| Open AccessA compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability
- Michele Vasaturo
- , Lorenzo Fiengo
- & Fabrizio Dal Piaz
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| Open AccessCostunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway
- Zhangxiao Peng
- , Yan Wang
- & Changqing Su
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| Open AccessA new serotonin 5-HT6 receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding
- Juan A. González-Vera
- , Rocío A. Medina
- & María L. López-Rodríguez
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Article
| Open AccessThe identification and molecular mechanism of anti-stroke traditional Chinese medicinal compounds
- Jia-Qian Liu
- , Shao-Xing Dai
- & Jing-Fei Huang
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Article
| Open AccessNLRP3 inflammasome: Pathogenic role and potential therapeutic target for IgA nephropathy
- Yu-Ling Tsai
- , Kuo-Feng Hua
- & Shuk-Man Ka
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Article
| Open AccessZebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells
- Kazuaki Nakamura
- , Kazuko Aizawa
- & Akito Tanoue
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Article
| Open AccessChitosan functionalized nanocochleates for enhanced oral absorption of cyclosporine A
- Min Liu
- , Xiaoming Zhong
- & Zhiwen Yang
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| Open AccessClick-Chemistry Based High Throughput Screening Platform for Modulators of Ras Palmitoylation
- Lakshmi Ganesan
- , Peyton Shieh
- & Ilya Levental
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| Open AccessLuteolin improves cardiac dysfunction in heart failure rats by regulating sarcoplasmic reticulum Ca2+-ATPase 2a
- Wenjing Hu
- , Tongda Xu
- & Dongye Li
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| Open AccessEnhanced intracellular delivery and antibacterial efficacy of enrofloxacin-loaded docosanoic acid solid lipid nanoparticles against intracellular Salmonella
- Shuyu Xie
- , Fei Yang
- & Zonghui Yuan
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| Open AccessPotentially high-risk medication categories and unplanned hospitalizations: a case–time–control study
- Chih-Wan Lin
- , Yu-Wen Wen
- & Fei-Yuan Hsiao
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| Open AccessPharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a
- Jennifer R. Deuis
- , Zoltan Dekan
- & Irina Vetter
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| Open AccessModification of distinct ion channels differentially modulates Ca2+ dynamics in primary cultured rat ventricular cardiomyocytes
- Xichun Li
- , Liping Shen
- & Zhengyu Cao
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| Open AccessThe clinically approved antiviral drug sofosbuvir inhibits Zika virus replication
- Carolina Q. Sacramento
- , Gabrielle R. de Melo
- & Thiago Moreno L. Souza
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Article
| Open AccessStructural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase
- He-Lin Yu
- , Shu-Heng Jiang
- & Min-Juan Xu
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| Open AccessCiproxifan, a histamine H3 receptor antagonist, reversibly inhibits monoamine oxidase A and B
- S. Hagenow
- , A. Stasiak
- & H. Stark
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| Open AccessTargeting pathogen metabolism without collateral damage to the host
- Jurgen R. Haanstra
- , Albert Gerding
- & Barbara M. Bakker
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| Open AccessIncreased Renal Clearance of Rocuronium Compensates for Chronic Loss of Bile Excretion, via upregulation of Oatp2
- Long Wang
- , Mai-Tao Zhou
- & Wei-Feng Yu
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Article
| Open AccessPredicting drug-target interactions by dual-network integrated logistic matrix factorization
- Ming Hao
- , Stephen H. Bryant
- & Yanli Wang
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| Open AccessTranscriptome and network analyses in Saccharomyces cerevisiae reveal that amphotericin B and lactoferrin synergy disrupt metal homeostasis and stress response
- Chi Nam Ignatius Pang
- , Yu-Wen Lai
- & Marc R. Wilkins
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| Open AccessHydroxysafflor yellow A attenuates the expression of inflammatory cytokines in acute soft tissue injury
- Fang Dong
- , Changjiang Xue
- & Baoxia Zang
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| Open AccessA Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins
- Tobias G. Kapp
- , Florian Rechenmacher
- & Horst Kessler
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| Open AccessNovel long-chain compounds with both immunomodulatory and MenA inhibitory activities against Staphylococcus aureus and its biofilm
- Seoung-ryoung Choi
- , Joel Frandsen
- & Prabagaran Narayanasamy
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| Open AccessElucidating the modes of action for bioactive compounds in a cell-specific manner by large-scale chemically-induced transcriptomics
- Michio Iwata
- , Ryusuke Sawada
- & Yoshihiro Yamanishi
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| Open AccessDrug Response Prediction as a Link Prediction Problem
- Zachary Stanfield
- , Mustafa Coşkun
- & Mehmet Koyutürk
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| Open AccessGastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer
- Yingdong Zhu
- , Fang Wang
- & Shengmin Sang
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| Open AccessAnalytical studies on ascosin, candicidin and levorin multicomponent antifungal antibiotic complexes. The stereostructure of ascosin A2
- Paweł Szczeblewski
- , Tomasz Laskowski
- & Edward Borowski
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| Open AccessUsing the “target constituent removal combined with bioactivity assay” strategy to investigate the optimum arecoline content in charred areca nut
- Wei Peng
- , Yu-Jie Liu
- & Chun-Jie Wu
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| Open AccessComparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System
- Chong Zhang
- , Ying Xu
- & James M. O’Donnell
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| Open AccessIdentification of Guanosine 5′-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway
- Stanzin Angmo
- , Neha Tripathi
- & Nitin Kumar Singhal
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| Open AccessIdentification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma
- José L. Neira
- , Jennifer Bintz
- & Olga Abián
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| Open AccessNetwork-Based Approach to Identify Potential Targets and Drugs that Promote Neuroprotection and Neurorepair in Acute Ischemic Stroke
- Yiwei Wang
- , Hailong Liu
- & Changkai Sun
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| Open AccessAminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome
- Teita Asano
- , Ken-ichiro Tanaka
- & Tohru Mizushima
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Article
| Open AccessIntercalative DNA binding of the marine anticancer drug variolin B
- Albert Canals
- , Raquel Arribas-Bosacoma
- & Miquel Coll