Disease model articles within Scientific Reports

Featured

• Article
  16 April 2024 | Open Access

  SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

  • Chiu Wang Chau
  • , Alex To
  •  & Ryohichi Sugimura

• Article
  03 April 2024 | Open Access

  Differentiation and functioning of the lateral line organ in zebrafish require Smpx activity

  • Alberto Diana
  • , Anna Ghilardi
  •  & Luca Del Giacco

• Article
  23 March 2024 | Open Access

  A defined diet for pre-adult Drosophila melanogaster

  • Felipe Martelli
  • , Annelise Quig
  •  & Matthew D. W. Piper

• Article
  21 March 2024 | Open Access

  MCU-independent Ca²⁺ uptake mediates mitochondrial Ca²⁺ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy

  • Michael J. Bround
  • , Eaman Abay
  •  & Jeffery D. Molkentin

• Article
  07 March 2024 | Open Access

  Dysregulation of miRNA–mRNA expression in fetal growth restriction in a caloric restricted mouse model

  • Lauren T. Gallagher
  • , James Bardill
  •  & S. Christopher Derderian

• Article
  04 March 2024 | Open Access

  Craniofacial bone anomalies related to cholesterol synthesis defects

  • Chihiro Iwaya
  • , Akiko Suzuki
  •  & Junichi Iwata

• Article
  23 January 2024 | Open Access

  The temporal progression of retinal degeneration and early-stage idebenone treatment in the Pde6b^rd1/rd1 mouse model of retinal dystrophy

  • Lei Zhang
  • , Wei Liu
  •  & Zuo-Ming Zhang

• Article
  11 January 2024 | Open Access

  Folate receptor overexpression induces toxicity in a diet-dependent manner in C. elegans

  • Bideep Shrestha
  • , Milla Tallila
  •  & Olli Matilainen

• Article
  03 January 2024 | Open Access

  The Rogdi knockout mouse is a model for Kohlschütter–Tönz syndrome

  • Alexandra Jimenez-Armijo
  • , Supawich Morkmued
  •  & Agnès Bloch-Zupan

• Article
  28 November 2023 | Open Access

  Long-term pulmonary and neurodevelopmental impairment in a fetal growth restriction rabbit model

  • Ignacio Valenzuela
  • , Yannick Regin
  •  & Johannes van der Merwe

• Article
  15 October 2023 | Open Access

  The suppression of MAPK/NOX/MMP signaling prompts renoprotection conferred by prenatal naproxen in weaning preeclamptic rats

  • Sherien A. Abdelhady
  • , Mennatallah A. Ali
  •  & Mahmoud M. El-Mas

• Article
  09 October 2023 | Open Access

  Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform

  • Alexander Ernst
  • , Indre Piragyte
  •  & Nadia Mercader

• Article
  25 July 2023 | Open Access

  Radiation makes cells select the form of death dependent on external or internal exposure: apoptosis or pyroptosis

  • Kazuko Shichijo
  • , Toshihiro Takatsuji
  •  & Masaharu Hoshi

• Article
  24 June 2023 | Open Access

  Multiobjective optimization to assess dengue control costs using a climate-dependent epidemiological model

  • Amália Soares Vieira de Vasconcelos
  • , Josenildo Silva de Lima
  •  & Rodrigo Tomás Nogueira Cardoso

• Article
  17 June 2023 | Open Access

  Single-cell transcriptomic profiling of microvascular endothelial cell heterogeneity in congenital diaphragmatic hernia

  • Jason O. Robertson
  • , Peter Bazeley
  •  & Kewal Asosingh

• Article
  26 April 2023 | Open Access

  A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis

  • Marian Seda
  • , Berta Crespo
  •  & Dagan Jenkins

• Article
  19 April 2023 | Open Access

  Dentin defects caused by a Dspp⁻¹ frameshift mutation are associated with the activation of autophagy

  • Tian Liang
  • , Charles E. Smith
  •  & James P. Simmer

• Article
  15 February 2023 | Open Access

  Developmental programming: adverse sexually dimorphic transcriptional programming of gestational testosterone excess in cardiac left ventricle of fetal sheep

  • Venkateswaran Ramamoorthi Elangovan
  • , Nadia Saadat
  •  & Arpita K. Vyas

• Article
  03 February 2023 | Open Access

  Post-GWAS screening of candidate genes for refractive error in mutant zebrafish models

  • Wim H. Quint
  • , Kirke C. D. Tadema
  •  & Adriana I. Iglesias

• Article
  10 January 2023 | Open Access

  Suppression of seizure in childhood absence epilepsy using robust control of deep brain stimulation: a simulation study

  • Ehsan Rouhani
  • , Ehsan Jafari
  •  & Amir Akhavan

• Article
  10 January 2023 | Open Access

  Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons

  • Linh Tran Nguyen Truc
  • , Satoshi Matsuda
  •  & Hiroyasu Tsukaguchi

• Article
  31 December 2022 | Open Access

  A Drosophila model of the neurological symptoms in Mpv17-related diseases

  • Atsushi Kodani
  • , Mizuki Yamaguchi
  •  & Hideki Yoshida

• Article
  02 December 2022 | Open Access

  Modelling the ecological dynamics of mosquito populations with multiple co-circulating Wolbachia strains

  • Samson T. Ogunlade
  • , Adeshina I. Adekunle
  •  & Michael T. Meehan

• Article
  19 November 2022 | Open Access

  Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome

  • Isabel Pijuan
  • , Elisa Balducci
  •  & Maria L. Arbonés

• Article
  14 November 2022 | Open Access

  Water provisioning increases caged worker bee lifespan and caged worker bees are living half as long as observed 50 years ago

  • Anthony Nearman
  •  & Dennis vanEngelsdorp

• Article
  29 October 2022 | Open Access

  Toxicology evaluation of overdose hydroxychloroquine on zebrafish (Danio rerio) embryos

  • Min Luo
  • , Dan Xie
  •  & Yanyan Liu

• Article
  22 June 2022 | Open Access

  Identification of large offspring syndrome during pregnancy through ultrasonography and maternal blood transcriptome analyses

  • Rocío Melissa Rivera
  • , Anna Katherine Goldkamp
  •  & Christine G. Elsik

• Article
  13 June 2022 | Open Access

  Maternal gastrointestinal nematode infection enhances spatial memory of uninfected juvenile mouse pups

  • Sophia C. Noel
  • , Liana Fortin-Hamel
  •  & Marilyn E. Scott

• Article
  13 May 2022 | Open Access

  BeCaked: An Explainable Artificial Intelligence Model for COVID-19 Forecasting

  • Duc Q. Nguyen
  • , Nghia Q. Vo
  •  & Tho T. Quan

• Article
  01 April 2022 | Open Access

  Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model

  • Jessica A. Jiménez
  • , Jeremy M. Simon
  •  & Mark J. Zylka

• Article
  29 March 2022 | Open Access

  In vitro ballooned hepatocytes can be produced by primary human hepatocytes and hepatic stellate cell sheets

  • Nobuhiro Hasui
  • , Katsuhisa Sakaguchi
  •  & Tatsuya Shimizu

• Article
  18 January 2022 | Open Access

  brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury

  • Vassili A. Kouprianov
  • , Aubrie A. Selmek
  •  & Heather R. Shive

• Article
  07 January 2022 | Open Access

  Decrease of Pdzrn3 is required for heart maturation and protects against heart failure

  • Mathieu Pernot
  • , Béatrice Jaspard-vinassa
  •  & Cécile Duplàa

• Article
  24 November 2021 | Open Access

  Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine

  • Elizabeth A. Pekarskaya
  • , Emma S. Holt
  •  & Sarah E. Canetta

• Article
  23 November 2021 | Open Access

  A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidates

  • Simon Ströbel
  • , Radina Kostadinova
  •  & Eva Thoma

• Article
  19 November 2021 | Open Access

  A novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior

  • Tomoe Seki
  • , Hirotaka Yamagata
  •  & Shin Nakagawa

• Article
  19 November 2021 | Open Access

  Physiological significance of WDR45, a responsible gene for β-propeller protein associated neurodegeneration (BPAN), in brain development

  • Mariko Noda
  • , Hidenori Ito
  •  & Koh-ichi Nagata

• Article
  27 October 2021 | Open Access

  The function of Scox in glial cells is essential for locomotive ability in Drosophila

  • Ryosuke Kowada
  • , Atsushi Kodani
  •  & Hideki Yoshida

• Article
  27 October 2021 | Open Access

  The effects of high-monosaccharide diets on development and biochemical composition of white-eyed mutant strain of house cricket (Acheta domesticus)

  • Jacek Francikowski
  • , Marta Potrzebska
  •  & Michał Krzyżowski

• Article
  21 October 2021 | Open Access

  Dual recombinase action in the normal and neoplastic mammary gland epithelium

  • Patrick D. Rädler
  • , Kerry Vistisen
  •  & Kay-Uwe Wagner

• Article
  13 October 2021 | Open Access

  Untargeted metabolomics reveals sex-specific differences in lipid metabolism of adult rats exposed to dexamethasone in utero

  • Alyssa Murray
  • , Sujeenthar Tharmalingam
  •  & T. C. Tai

• Article
  12 October 2021 | Open Access

  A modified animal model of hepatic regeneration induced by hilar bile duct ligation

  • Tao Li
  • , Yichao Chai
  •  & Liangshuo Hu

• Article
  29 September 2021 | Open Access

  Quantitative behavioural phenotyping to investigate anaesthesia induced neurobehavioural impairment

  • Pratheeban Nambyiah
  •  & Andre E. X. Brown

• Article
  24 September 2021 | Open Access

  In vivo analysis of onset and progression of retinal degeneration in the Nr2e3^rd7/rd7 mouse model of enhanced S-cone sensitivity syndrome

  • Giulia Venturini
  • , Despina Kokona
  •  & Pascal Escher

• Article
  25 August 2021 | Open Access

  Automated computational analysis reveals structural changes in the enteric nervous system of nNOS deficient mice

  • Ben R. Cairns
  • , Benjamin Jevans
  •  & Conor J. McCann

• Article
  23 July 2021 | Open Access

  Loss of αklotho causes reduced motor ability and short lifespan in zebrafish

  • Yurie Ogura
  • , Ryoji Kaneko
  •  & Hiromi Hirata

• Article
  17 May 2021 | Open Access

  Developmental and lifelong dioxin exposure induces measurable changes in cardiac structure and function in adulthood

  • Matthew de Gannes
  • , Sheryl E. Koch
  •  & Jack Rubinstein

• Article
  05 May 2021 | Open Access

  A novel RLIM/RNF12 variant disrupts protein stability and function to cause severe Tonne–Kalscheuer syndrome

  • Francisco Bustos
  • , Carmen Espejo-Serrano
  •  & Greg M. Findlay

• Article
  21 April 2021 | Open Access

  Alternative redox forms of ASNA-1 separate insulin signaling from tail-anchored protein targeting and cisplatin resistance in C. elegans

  • Dorota Raj
  • , Ola Billing
  •  & Peter Naredi

• Article
  24 February 2021 | Open Access

  Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways

  • Natalia El-Merhie
  • , Arne Krüger
  •  & Susanne Krauss-Etschmann