Diagnosis articles within Nature

Featured

  • Article |

    A biosensor comprising bacteria engineered to respond to transient inflammatory signals has been packaged with electronic readout and transmission circuits in a small device that could be swallowed to monitor gastrointestinal health.

    • M. E. Inda-Webb
    • , M. Jimenez
    •  & T. K. Lu

  • Article |

    A deep-learning-based algorithm uses routinely acquired histology slides to provide a differential diagnosis for the origin of the primary tumour for complicated cases of metastatic tumours and cancers of unknown primary origin.

    • Ming Y. Lu
    • , Tiffany Y. Chen
    •  & Faisal Mahmood

  • Review Article |

    Combining mobile phone technologies with infectious disease diagnostics can increase patients’ access to testing and treatment and provide public health authorities with new ways to monitor and control outbreaks of infectious diseases.

    • Christopher S. Wood
    • , Michael R. Thomas
    •  & Molly M. Stevens

  • Outlook |

    Epilepsy arises from natural mechanisms in the brain that go awry. Researchers are trying to unravel its complexities.

    • Michael Eisenstein

  • Outlook |

    From image-analysis software to lens-free microscopes that fit on a mobile phone, new tools are providing pathologists with clearer and more informative images.

    • Katherine Bourzac

  • News |

    Human excreta could be a powerful source of cells to study disease, bypassing some of the problems of using stem cells.

    • Monya Baker

  • Comment |

    Without better regulation, non-invasive prenatal genetic tests will be targeted by US anti-abortion lobbyists, argues Jaime S. King.

    • Jaime S. King

  • Outlook |

    Draft diagnostic guidelines are raising concerns that mild forms of the disorder may no longer be recognized.

    • Emily Singer

  • Outlook |

    The first symptoms of COPD can be subtle, so the disease often goes undiagnosed. Researchers are searching for ways to detect the disease and to identify those most at risk.

    • Cassandra Willyard

  • Outlook |

    COPD is one of the world's biggest killers, but awareness is low, diagnosis is often missed, and in many countries the extent of the problem is not even well-documented.

    • Amber Dance

  • News |

    The extension of 'grimace scales' highlights their growing role in research.

    • Daniel Cressey

  • Outlook |

    Pap tests have been a mainstay of cervical cancer screening, but new tests, vaccines and knowledge might be changing that, including when and how frequently to test.

    • Courtney Humphries

  • News & Views |

    The genome sequence of a fetus can be inferred from the relative numbers of variants of DNA sequences in a pregnant woman's blood. This advance in non-invasive diagnostics comes with some ramifications. See Article p.320

    • Diana W. Bianchi

  • Article |

    Prenatal testing usually requires invasive sampling; here molecular counting of parental haplotypes in the maternal plasma allows the fetal genome to be deciphered and molecular counting of individual alleles enables the fetal exome to be captured.

    • H. Christina Fan
    • , Wei Gu
    •  & Stephen R. Quake

  • News & Views |

    Rare tumour cells with mutations that confer drug resistance can go undetected by standard testing procedures, according to two studies, which show that such mutations can be detected in patients' blood. See Letters p.532 and p.537

    • Eduardo Vilar
    •  & Josep Tabernero

  • Outlook |

    Technologies that better reveal the insidious progression of multiple sclerosis could aid the search for treatments.

    • Cynthia Graber

  • Letter |

    Transplanting bone marrow from wild-type mice into MECP2-lacking mice results in wild-type microglial engraftment, extends lifespan and reduces symptoms of disease such as breathing and locomotor abnormalities, implicating microglia in the pathophysiology of Rett syndrome.

    • Noël C. Derecki
    • , James C. Cronk
    •  & Jonathan Kipnis

  • Letter |

    Selective impairment of peripheral regulatory T-cell differentiation is found to result in spontaneous allergic TH2-type inflammation in the intestine and lungs, demonstrating the functional heterogeneity of regulatory T cells generated in the thymus and extrathymically in controlling immune mediated inflammation and disease.

    • Steven Z. Josefowicz
    • , Rachel E. Niec
    •  & Alexander Y. Rudensky

  • News |

    Scientists call for stricter biosafety measures for dangerous avian-influenza variants.

    • Declan Butler

  • Brief Communications Arising |

    • Christopher J. Phiel
    • , Christina A. Wilson
    •  & Peter S. Klein

  • Article |

    The mutations that underlie the diseases tuberous sclerosis complex and fragile X syndrome produce abnormalities in synaptic plasticity and function that can be corrected by treatments that modulate metabotropic glutamate receptor 5 in opposite directions.

    • Benjamin D. Auerbach
    • , Emily K. Osterweil
    •  & Mark F. Bear

  • Q&A |

    Chemical pathologist makes breakthroughs in fetal-disease diagnostics.

    • Virginia Gewin

  • Editorial |

    Screening of newborns for genetic disorders is important, but so is educating parents to ensure that they give the proper consent.

  • News Feature |

    By raising hell about newborn blood-spot screening, Twila Brase could jeopardize public-health programmes and derail research. The problem is, she has a point.

    • Mary Carmichael

  • News & Views |

    Autism spectrum disorders vary greatly in severity. By including children in regular education who received no special help, an epidemiological study has found these disorders to be up to three times more prevalent than thought.

    • Catherine Lord

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