Rare tumour cells with mutations that confer drug resistance can go undetected by standard testing procedures, according to two studies, which show that such mutations can be detected in patients' blood. See Letters p.532 and p.537
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References
Misale, S. et al. Nature 486, 532–536 (2012).
Diaz, L. A. Jr et al. Nature 486, 537–540 (2012).
Diehl, F. et al. Nature Methods 3, 551–559 (2006).
Montagut, C. et al. Nature Med. 18, 221–223 (2012).
Edkins, S. et al. Cancer Biol. Ther. 5, 928–932 (2006).
Marusyk, A., Almendro, V. & Polyak, K. Nature Rev. Cancer 12, 323–334, (2012).
Yap, T. A., Gerlinger, M., Futreal, P. A., Pusztai, L. & Swanton, C. Sci. Transl. Med. 4, 127ps10 (2012).
Gerlinger, M. et al. N. Engl. J. Med. 366, 883–892 (2012).
Diehl, F. et al. Nature Med. 14, 985–990 (2008).
Forshew, T. et al. Sci. Transl. Med. 4, 136ra68 (2012).
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Vilar, E., Tabernero, J. Pinprick diagnostics. Nature 486, 482–483 (2012). https://doi.org/10.1038/486482a
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DOI: https://doi.org/10.1038/486482a
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