Pathology articles within Nature

Featured

  • Article |

    A deep-learning-based algorithm uses routinely acquired histology slides to provide a differential diagnosis for the origin of the primary tumour for complicated cases of metastatic tumours and cancers of unknown primary origin.

    • Ming Y. Lu
    • , Tiffany Y. Chen
    •  & Faisal Mahmood

  • Outlook |

    From image-analysis software to lens-free microscopes that fit on a mobile phone, new tools are providing pathologists with clearer and more informative images.

    • Katherine Bourzac

  • Letter |

    Transplanting bone marrow from wild-type mice into MECP2-lacking mice results in wild-type microglial engraftment, extends lifespan and reduces symptoms of disease such as breathing and locomotor abnormalities, implicating microglia in the pathophysiology of Rett syndrome.

    • Noël C. Derecki
    • , James C. Cronk
    •  & Jonathan Kipnis

  • Letter |

    Selective impairment of peripheral regulatory T-cell differentiation is found to result in spontaneous allergic TH2-type inflammation in the intestine and lungs, demonstrating the functional heterogeneity of regulatory T cells generated in the thymus and extrathymically in controlling immune mediated inflammation and disease.

    • Steven Z. Josefowicz
    • , Rachel E. Niec
    •  & Alexander Y. Rudensky

  • Brief Communications Arising |

    • Christopher J. Phiel
    • , Christina A. Wilson
    •  & Peter S. Klein

  • Article |

    The mutations that underlie the diseases tuberous sclerosis complex and fragile X syndrome produce abnormalities in synaptic plasticity and function that can be corrected by treatments that modulate metabotropic glutamate receptor 5 in opposite directions.

    • Benjamin D. Auerbach
    • , Emily K. Osterweil
    •  & Mark F. Bear

  • Article |

    PPARγ ligands are used to control diabetes, but their anti-diabetic actions are puzzling. Here the authors show that phosphorylation of PPARγ by cyclin-dependent kinase 5 (Cdk5) in mice is linked to obesity induced by high-fat feeding, and that inhibition of the effect in humans by the drug rosiglitazone is closely associated with its anti-diabetic effects. Several anti-diabetic PPARγ ligands directly inhibit the effect, and thus support a more normal non-diabetic pattern of gene expression.

    • Jang Hyun Choi
    • , Alexander S. Banks
    •  & Bruce M. Spiegelman

Browse broader subjects

Browse Pathology across other nature.com journals