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| Open AccessTargeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models
- Silvia La Monica
- , Federica Vacondio
- & Roberta Alfieri
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| Open AccessImpact of LKB1 status on radiation outcome in patients with stage III non-small-cell lung cancer
- Piyada Sitthideatphaiboon
- , Chonnipa Nantavithya
- & Virote Sriuranpong
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| Open AccessThe effect of myeloablative radiation on urinary bladder mast cells
- Jessica Smith
- , Jonathan Kah Huat Tan
- & Christian Moro
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| Open AccessMulti-scale geometric network analysis identifies melanoma immunotherapy response gene modules
- Kevin A. Murgas
- , Rena Elkin
- & Allen R. Tannenbaum
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| Open AccessNortriptyline hydrochloride, a potential candidate for drug repurposing, inhibits gastric cancer by inducing oxidative stress by triggering the Keap1-Nrf2 pathway
- Chunyang Zhu
- , Yangyang Lu
- & Weiwei Qi
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| Open AccessClassical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation
- Feier Zeng
- , Abbie Wade
- & Aymen I. Idris
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| Open AccessA novel T cell-redirecting anti-GPRC5D × CD3 bispecific antibody with potent antitumor activity in multiple myeloma preclinical models
- Urara Tomita
- , Yoko Ishimoto
- & Toshinori Agatsuma
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| Open AccessReversing immunosuppression in the tumor microenvironment of fibrolamellar carcinoma via PD-1 and IL-10 blockade
- S. K. Daniel
- , K. M. Sullivan
- & V. G. Pillarisetty
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| Open AccessA study combining microbubble-mediated focused ultrasound and radiation therapy in the healthy rat brain and a F98 glioma model
- Stecia-Marie P. Fletcher
- , Amanda Chisholm
- & Nathan McDannold
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| Open AccessExploring prognostic factors and treatment strategies for long-term survival in pleomorphic xanthoastrocytoma patients
- Chaejin Lee
- , Yukyeng Byeon
- & Sang Woo Song
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| Open AccessNLCECA score: a serum inflammatory-tumor biomarker score to predict survival of advanced perihilar cholangiocarcinoma after hepatic arterial infusion chemotherapy
- Shjie Fu
- , Jie Li
- & Xiaodong Wang
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| Open AccessExpression of the checkpoint kinase BUB1 is a predictor of response to cancer therapies
- Ylenia Cicirò
- , Denise Ragusa
- & Arturo Sala
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| Open AccessInhibition of epigenetic and cell cycle-related targets in glioblastoma cell lines reveals that onametostat reduces proliferation and viability in both normoxic and hypoxic conditions
- Darja Lavogina
- , Mattias Kaspar Krõlov
- & Jana Jaal
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| Open AccessCorrelation between surrogate endpoints and overall survival in unresectable hepatocellular carcinoma patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis
- Litao Huang
- , Deying Kang
- & Xueting Liu
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| Open AccessPerformance analysis and knowledge-based quality assurance of critical organ auto-segmentation for pediatric craniospinal irradiation
- Emeline M. Hanna
- , Emma Sargent
- & Ozgur Ates
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| Open AccessNeutrophil to lymphocyte ratio may predict efficacy of anti-PD-1 inhibitors in advanced EGFR-mutant non-small cell lung cancer: retrospective cohort study
- Jianxin Chen
- , Qinhong Zheng
- & Junhui Wang
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| Open AccessNeutrophil extracellular trap-associated risk index for predicting outcomes and response to Wnt signaling inhibitors in triple-negative breast cancer
- Zhidong Huang
- , Jinhui Wang
- & Hong Liu
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| Open AccessPacritinib inhibits proliferation of primary effusion lymphoma cells and production of viral interleukin-6 induced cytokines
- Yiquan Wu
- , Victoria Wang
- & Robert Yarchoan
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| Open AccessTargeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia
- Henri Colyn Bwanika
- , Isabelle Rose Leo
- & Katja Pokrovskaja Tamm
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| Open AccessRisk-adapted locoregional radiotherapy strategies based on a prognostic nomogram for de novo metastatic nasopharyngeal carcinoma patients treated with chemoimmunotherapy
- Yuebing Chen
- , Chuying Chen
- & Cheng Lin
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| Open AccessBAMLET administration via drinking water inhibits intestinal tumor development and promotes long-term health
- Hien Thi Tran
- , Murphy Lam Yim Wan
- & Catharina Svanborg
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| Open AccessAn inflamed tumor cell subpopulation promotes chemotherapy resistance in triple negative breast cancer
- Mauricio Jacobo Jacobo
- , Hayley J. Donnella
- & Sourav Bandyopadhyay
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Article
| Open AccessDistinguishing recurrence from radiation-induced lung injury at the time of RECIST progressive disease on post-SABR CT scans using radiomics
- Salma Dammak
- , Stephanie Gulstene
- & Aaron D. Ward
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Article
| Open AccessThe Temozolomide–Doxorubicin paradox in Glioblastoma in vitro–in silico preclinical drug-screening
- Mariam-Eleni Oraiopoulou
- , Eleftheria Tzamali
- & Vangelis Sakkalis
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| Open AccessComparative assessment of direct and indirect cold atmospheric plasma effects, based on helium and argon, on human glioblastoma: an in vitro and in vivo study
- Mahdiyeh Bakhtiyari-Ramezani
- , Mojtaba Nohekhan
- & Meysam Nasiri
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| Open AccessNavigating the nuances: comparative analysis and hyperparameter optimisation of neural architectures on contrast-enhanced MRI for liver and liver tumour segmentation
- Felix Quinton
- , Benoit Presles
- & Jean-Louis Alberini
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| Open AccessA TME-activated nano-catalyst for triple synergistic therapy of colorectal cancer
- Qiang Liu
- , Yurong Xiang
- & Zheng Xiang
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| Open AccessComparative overall survival of CDK4/6 inhibitors in combination with endocrine therapy in advanced breast cancer
- Coralea Kappel
- , Mitchell J. Elliott
- & Eitan Amir
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| Open AccessMolecular crosstalk between MUC1 and STAT3 influences the anti-proliferative effect of Napabucasin in epithelial cancers
- Mukulika Bose
- , Alexa Sanders
- & Pinku Mukherjee
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| Open AccessZFP36 disruption is insufficient to enhance the function of mesothelin-targeting human CAR-T cells
- David Mai
- , Tifara Boyce
- & Carl H. June
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Article
| Open AccessExtending deterministic transport capabilities for very-high and ultra-high energy electron beams
- Ahmed Naceur
- , Charles Bienvenue
- & Jean-François Carrier
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| Open AccessA novel exosome based therapeutic intervention against neuroendocrine prostate cancer
- Sharanjot Saini
- , Amritha Sreekumar
- & Matthew N. Simmons
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| Open AccessIn vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway
- Shaimaa E. Diab
- , Nourhan A. Tayea
- & Zakia A. Olama
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| Open AccessSingle-cell analysis reveals ADGRL4+ renal tubule cells as a highly aggressive cell type in clear cell renal cell carcinoma
- Zehua Wang
- & Zhongxiao Zhang
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| Open AccessThe boundary of posterior to level V region and the theoretical feasibility of irradiation dose reduction of level Va in nasopharyngeal carcinoma
- Chaoyang Jiang
- , Xiaokai Li
- & Juan Wang
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| Open AccessA novel CT-based radiomics model for predicting response and prognosis of chemoradiotherapy in esophageal squamous cell carcinoma
- Akinari Kasai
- , Jinsei Miyoshi
- & Tetsuji Takayama
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| Open AccessTranscriptomic and proteomic analysis of tumor suppressive effects of GZ17-6.02 against mycosis fungoides
- Zachary A. Bordeaux
- , Sriya V. Reddy
- & Madan M. Kwatra
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| Open AccessTherapy-induced modulation of tumor vasculature and oxygenation in a murine glioblastoma model quantified by deep learning-based feature extraction
- Nadine Bauer
- , Daniel Beckmann
- & Friedemann Kiefer
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| Open AccessImpact of glucose metabolism on PD-L1 expression in sorafenib-resistant hepatocellular carcinoma cells
- Sua Cho
- , Wonjin Kim
- & Misu Lee
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| Open AccessA new (T-X\(^\theta\)) family of distributions: properties, discretization and estimation with applications
- Rasha M. Mandouh
- , Mahmoud R. Mahmoud
- & Rasha E. Abdelatty
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| Open AccessDevelopment of a claims-based risk-scoring model to predict emergency department visits in older patients receiving anti-neoplastic therapy
- Yewon Suh
- , Jonghyun Jeong
- & Ju-Yeun Lee
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| Open AccessPrognostic significance of pretreatment albumin–bilirubin (ALBI) grade and platelet–albumin–bilirubin (PALBI) grade in patients with small cell lung cancer
- Engin Kut
- & Serkan Menekse
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| Open AccessPreparation of stable colloidal dispersion of surface modified Fe3O4 nanoparticles for magnetic heating applications
- Behnam Sabzi Dizajyekan
- , Arezou Jafari
- & Zahra Fakhroueian
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Editorial
| Open AccessAdvancing cancer immunotherapy: from innovative preclinical models to clinical insights
The rapid expansion of cancer immunology and immunotherapy builds upon the success of early immune checkpoint inhibitors (ICI) and chimeric antigen receptor T cells for some cancer types. Many gaps still exist, however, in the scientific knowledge of immune dysfunction in the tumour microenvironment and predicting clinical immunotherapy response to allow more cancer patients to benefit from immunotherapy. The Cancer Immunotherapy Collection within Scientific Reports describes pioneering preclinical and clinical studies addressing these concepts, representing significant insights and breakthroughs in the field.
- Andrew W. Craig
- , Hermann B. Frieboes
- & Paula A. Videira
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| Open AccessChemotherapy is of prognostic significance to metaplastic breast cancer
- Meilin Zhang
- , Jingjing Yuan
- & Hongliang Chen
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| Open AccessEffectiveness of adjuvant systemic therapy following complete cytoreductive surgery in patients with recurrent granulosa cell tumours of the ovary
- Harika Yumru Celiksoy
- , Catriona Dickie
- & Christina Fotopoulou
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| Open AccessPaclitaxel-induced inhibition of NSCLC invasion and migration via RBFOX3-mediated circIGF1R biogenesis
- Zhanyu Xu
- , Liping Zheng
- & Shikang Li
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| Open AccessRadiation-induced changes in energy metabolism result in mitochondrial dysfunction in salivary glands
- Lauren G. Buss
- , Brenna A. Rheinheimer
- & Kirsten H. Limesand
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| Open AccessFGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models
- Kristianne J. C. Galpin
- , Galaxia M. Rodriguez
- & Barbara C. Vanderhyden