Year in Review |
Featured
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Review Article |
Intracranial aneurysms: from vessel wall pathology to therapeutic approach
Intracranial arterial aneurysms can pose life-threatening risks to patients, so understanding the cause and the progression of these lesions is important for choosing the right treatment. This Review argues that aneurysms are a symptom of an underlying vascular disease rather than constituting a disease on their own. The authors classify intracranial aneurysms by vessel wall pathology and demonstrate that knowledge of the morphology and pathology of this structure is important in determining the therapeutic approach.
- Timo Krings
- , Daniel M. Mandell
- & Franz-Josef Hans
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News & Views |
Predicting outcomes after perinatal brain injury
Perinatal brain injury is associated with a substantial risk of long-term disability. A recent study has shown that the severity of injury to the deep nuclear gray matter and brainstem, determined by early MRI, correlates with the risk of death and/or cerebral palsy at 2 years.
- Terrie E. Inder
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Review Article |
Diagnosis and treatment of neurocysticercosis
Neurocysticercosis (caused by infection with the tapewormTaenia solium) is a major cause of acquired seizures and epilepsy worldwide. Nash and Garcia describe the different types of neurocysticercosis infection and discuss the role of the host inflammatory response in disease pathology. They also highlight recent advances in the diagnosis and treatment of the disease, including the limitations of current therapies.
- Theodore E. Nash
- & Hector H. Garcia
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News & Views |
Othello syndrome—at the interface of neurology and psychiatry
Othello syndrome, as demonstrated by Shakespeare's fictional character of that name, describes individuals with severe delusional jealousy. Retrospective analysis of data from patients with this syndrome suggests that it is frequently associated with neurological disorders, particularly those affecting the right frontal lobe. What are the implications of these findings?
- Richard Camicioli
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Review Article |
Virtual imaging laboratories for marker discovery in neurodegenerative diseases
Research in neurodegenerative disease is generating vast neuroimaging data sets, necessitating the development of powerful new e-infrastructures for data collection, storage, access and analysis. In this article, Frisoni et al. provide an overview of the currently available e-infrastructures—LONI, neuGRID and CBRAIN—and consider how computational neuroscience in neurodegenerative disease might evolve in the future.
- Giovanni B. Frisoni
- , Alberto Redolfi
- & Alan C. Evans
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Review Article |
White matter lesions in Parkinson disease
Age-associated white matter lesions are commonly observed in patients with idiopathic Parkinson disease, and are expected to contribute to the clinical symptoms in this condition. Bohnen and Albin review the literature addressing the occurrence and effects of white matter lesions in Parkinson disease, as well as describing existing and emerging methods for studying white matter pathology.
- Nicolaas I. Bohnen
- & Roger L. Albin
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Review Article |
Can neuroimaging studies identify pain endophenotypes in humans?
Much is still to be learned regarding how nociceptive stimuli, genes and various other factors influence the generation and maintenance of pain. In this article, Irene Tracey examines possible neuroimaging endophenotypes of pain that could act as measurable markers of this condition. Such markers would assist both the management of and research into acute and chronic pain.
- Irene Tracey
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Review Article |
The neurobiology of cognitive disorders in temporal lobe epilepsy
Memory impairment is a major complicating feature of temporal lobe epilepsy (TLE), and our understanding of such cognitive disorders has been enhanced by the study of anterior temporal lobectomy outcomes. In this Review, Bell and colleagues examine the changing view of TLE, and explore the anatomical abnormalities that underlie cognitive impairments that extend beyond memory function.
- Brian Bell
- , Jack J. Lin
- & Bruce Hermann
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Opinion |
Benign mesial temporal lobe epilepsy
Labate et al. argue that benign mesial temporal lobe epilepsy (bMTLE)—defined as at least 24 months of seizure freedom with or without antiepileptic medication—has been under-recognized because of a bias in the literature towards refractory forms of epilepsy. Here, the authors discuss emerging concepts on bMTLE, some of which were formulated during an international workshop held in Italy.
- Angelo Labate
- , Antonio Gambardella
- & Frederick Andermann
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Case Study |
Extreme hypoglycorrhachia: not always bacterial meningitis
Extreme hypoglycorrhachia is usually caused by bacterial meningitis; however, suspicion should be raised if a patient with persistent extreme hypoglycorrhachia, pleocytosis and negative microbiological studies remains refractory to antimicrobial therapy. Viola describes the case of a 55-year-old man with chronic leptomeningitis and persistent hypoglycorrhachia, who was found to have Currarino syndrome. This syndrome is a complex genetic disorder that includes the following triad: sacral bony defect, presacral mass, and an anorectal malformation. Leptomeningitis in this patient was attributed to cholesterol crystals contained in a large presacral cyst with a communicating fistula to the CNS.
- George M. Viola
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Review Article |
Imaging in the surgical treatment of epilepsy
Surgical intervention can represent an effective treatment for some patients with medically refractory epilepsy. In this Review, Duncan explores the various imaging techniques that can be used in epilepsy surgery to identify the epileptic source and/or to reduce the risk of surgery-related morbidity. In addition to examining established clinical practice, Duncan highlights recent advances in this field.
- John S. Duncan
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