Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Pediatrics

Predicting outcomes after perinatal brain injury

Nature Reviews Neurology volume 7, pages 544–545 (2011)Cite this article

Subjects

Perinatal brain injury is associated with a substantial risk of long-term disability. A recent study has shown that the severity of injury to the deep nuclear gray matter and brainstem, determined by early MRI, correlates with the risk of death and/or cerebral palsy at 2 years.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Nelson, K. B. & Leviton, A. How much of neonatal encephalopathy is due to birth asphyxia? Am. J. Dis. Child. 145, 1325–1331 (1991).

    Article  CAS  Google Scholar 

  2. Ferriero, D. M. Neonatal brain injury. N. Engl. J. Med. 351, 1985–1995 (2004).

    Article  CAS  Google Scholar 

  3. Finer, N. N., Robertson, C. M., Richards, R. T., Pinnell, L. E. & Peters, K. L. Hypoxic–ischemic encephalopathy in term neonates: perinatal factors and outcome. J. Pediatr. 98, 112–117 (1981).

    Article  CAS  Google Scholar 

  4. Martinez-Biarge, M. et al. Predicting motor outcome and death in term hypoxic–ischemic encephalopathy. Neurology 76, 2055–2061 (2011).

    Article  CAS  Google Scholar 

  5. Cowan, F. et al. Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet 361, 736–742 (2003).

    Article  Google Scholar 

  6. Myers, R. E. Four patterns of perinatal brain damage and their conditions of occurrence in primates. Adv. Neurol. 10, 223–234 (1975).

    CAS  PubMed  Google Scholar 

  7. Rutherford, M. A. et al. Abnormal magnetic resonance signal in the internal capsule predicts poor neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy. Pediatrics 102, 323–328 (1998).

    Article  CAS  Google Scholar 

  8. Azzopardi, D. V. et al. TOBY Study Group. Moderate hypothermia to treat perinatal asphyxia. N. Engl. J. Med. 361, 1349–1358 (2009).

    Article  CAS  Google Scholar 

  9. Woischnek, D. et al. Prognosis of brain stem lesions in children with head injury. Child. Nerv. Syst. 19, 174–178 (2003).

    Google Scholar 

  10. Martinez-Biarge, M., Diez-Sebastian, J., Rutherford, M. A. & Coan, F. M. Outcomes after central grey matter injury in term perinatal hypoxic–ischemic encephalopathy. Early Hum. Dev. 86, 675–682 (2010).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Washington University in St Louis, 660 South Euclid Avenue, St Louis, 63110, MO, USA

    Terrie E. Inder

Authors
  1. Terrie E. Inder
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Inder, T. Predicting outcomes after perinatal brain injury. Nat Rev Neurol 7, 544–545 (2011). https://doi.org/10.1038/nrneurol.2011.142

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2011.142

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing