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Dementia in 2011

Microbleeds in dementia—singing a different ARIA

In 2011, researchers used imaging techniques to investigate brain microbleeds in patients with dementia and highlighted how lobar microbleeds could be used as a marker for amyloid pathology and for predicting mortality. New guidelines on the inclusion and exclusion of participants with microbleeds in anti-amyloid clinical trials were also published.

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Figure 1: Brain microbleeds on MRI.

References

  1. Cordonnier, C. & van der Flier, W. M. Brain microbleeds and Alzheimer's disease: innocent observation or key player? Brain 134, 335–344 (2011).

    Article  PubMed  Google Scholar 

  2. Henneman, W. J. et al. MRI biomarkers of vascular damage and atrophy predicting mortality in a memory clinic population. Stroke 40, 492–498 (2009).

    Article  PubMed  Google Scholar 

  3. Yates, P. A. et al. Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease. Neurology 77, 48–54 (2011).

    Article  CAS  PubMed  Google Scholar 

  4. Goos, J. D. C. et al. Microbleeds relate to altered amyloid-β metabolism in Alzheimer disease. Neurobiol. Aging http://dx.doi.org/10.1016/j.neurobiolaging.2011.10.026.

  5. Altmann–Schneider, I. et al. Cerebral microbleeds are predictive of mortality in the elderly. Stroke 42, 638–644 (2011).

    Article  PubMed  Google Scholar 

  6. Sperling, R. A. et al. Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement. 7, 367–385 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Goos, J. D. C. et al. Clinical relevance of improved microbleed detection by susceptibility-weighted magnetic resonance imaging. Stroke 42, 1894–1900 (2011).

    Article  PubMed  Google Scholar 

  8. De Reuck, J. et al. Comparison of 7.0-T T2*-magnetic resonance imaging of cerebral bleeds in post-mortem brain sections of Alzheimer patients with their neuropathological correlates. Cerebrovasc. Dis. 31, 511–517 (2011).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Philip Scheltens.

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Scheltens, P., Goos, J. Microbleeds in dementia—singing a different ARIA. Nat Rev Neurol 8, 68–70 (2012). https://doi.org/10.1038/nrneurol.2011.222

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