Featured
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Two-way magnetic resonance tuning and enhanced subtraction imaging for non-invasive and quantitative biological imaging
A distance-dependent two-way magnetic resonance tuning platform combined with dual-contrast enhanced subtraction imaging enables quantitative sensing and imaging in deep tissues with minimal background noise.
- Zhongling Wang
- , Xiangdong Xue
- & Yuanpei Li
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Article |
Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing
The addition of selective organ targeting molecules to nanoparticles allows the specific targeting of extrahepatic tissues, enabling gene editing of distinct cell populations outside the liver.
- Qiang Cheng
- , Tuo Wei
- & Daniel J. Siegwart
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Letter |
Matrix mechanics and water permeation regulate extracellular vesicle transport
Stress relaxation properties of the matrix as well as water transport through aquaporin-1 enable extracellular vesicles to deform and travel through the dense mesh of the extracellular matrix between cells.
- Stephen Lenzini
- , Raymond Bargi
- & Jae-Won Shin
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Article |
Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis
Single-walled carbon nanotubes can restore phagocytotic properties of macrophages in artherosclerotic plaques to promote plaque clearance and combat artherosclerosis.
- Alyssa M. Flores
- , Niloufar Hosseini-Nassab
- & Nicholas J. Leeper
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Letter |
Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis
Adoptive transfer of macrophages, transfected with vitamin C lipid nanoparticles that deliver an antimicrobial peptide and cathepsin B mRNA, can be applied for the treatment of multidrug-resistant bacteria-induced sepsis in mice.
- Xucheng Hou
- , Xinfu Zhang
- & Yizhou Dong
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Perspective |
Smart cancer nanomedicine
The use of nanomedicine in cancer requires the adoption of specific strategies to optimize its potential. This perspective proposes four strategies including the identification of patients for clinical trials, investments in modular nanocarrier design, the integration in multimodal combination therapy regimes and the inclusion in immunotherapy studies
- Roy van der Meel
- , Einar Sulheim
- & Twan Lammers
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Letter |
A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing
Polymer nanocapsules, assembled around a ribonucleoprotein complex of Cas9 nuclease and a single-guide RNA, enable safe and efficient gene editing in vitro and in vivo.
- Guojun Chen
- , Amr A. Abdeen
- & Shaoqin Gong
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Article |
Renal clearable catalytic gold nanoclusters for in vivo disease monitoring
Catalytic gold nanoclusters that respond to protease activity in vivo and are excreted in urine can offer a quick colorimetric tool for disease detection in resource-limited settings.
- Colleen N. Loynachan
- , Ava P. Soleimany
- & Molly M. Stevens
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Article |
Computational design of three-dimensional RNA structure and function
Automated 3D design produces rapid and near-atomically accurate predictions of RNA tertiary structure as well as the ability to generate complex RNA machines such as functional single-stranded tethered ribosomes, and enhancement of the binding properties of small-molecule RNA aptamers.
- Joseph D. Yesselman
- , Daniel Eiler
- & Rhiju Das
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Letter |
Remotely controlled chemomagnetic modulation of targeted neural circuits
Controlled delivery of neuromodulators in the brain might improve the understanding of the molecular basis of behaviour. In this letter, magnetic liposomes injected in deep brain regions release small molecules under remote magnetic stimulation, activating specific neuronal circuits in freely moving mice.
- Siyuan Rao
- , Ritchie Chen
- & Polina Anikeeva
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Article |
Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators
Combination of dendritic-cell-targeted nanovaccines with a myeloid-derived suppressor cell inhibitor and immune checkpoint modulators expands the host antitumour immune cells, restricts tumour growth and prolongs survival in orthotopic melanoma models.
- João Conniot
- , Anna Scomparin
- & Helena F. Florindo
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Review Article |
An atlas of nano-enabled neural interfaces
This Review highlights the progress made so far in engineering nanomaterials for neurotechnology applications, from neuron signal sensing and modulation to brain stimulation, with an outlook on what these technologies can enable in the future.
- Héctor Acarón Ledesma
- , Xiaojian Li
- & Bozhi Tian
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News & Views |
Transcellular transfer of nanomedicine
Nanoparticles designed to harness transcytosis achieve deeper tumour penetration.
- Hae Lin Jang
- & Shiladitya Sengupta
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News & Views |
Curving neural nanobioelectronics
Three-dimensional nanowire transistors with curvilinear tips record intracellular signals from neurons.
- Yin Fang
- & Bozhi Tian
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Article |
Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy
A zwitterionic camptothecin–polymer conjugate that is enzymatically transformed in a cationic molecule at the tumour periphery penetrates deep into tumours via caveolae-mediated endocytosis and transcytosis, resulting in high anticancer efficiency in vivo.
- Quan Zhou
- , Shiqun Shao
- & Youqing Shen
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Article |
Soil mobility of synthetic and virus-based model nanopesticides
Virus nanoparticles can penetrate soil to a depth of 30 cm, thus showing potential to effectively deliver nanopesticides.
- Paul L. Chariou
- , Alan B. Dogan
- & Nicole F. Steinmetz
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Article |
FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels
Administration of the clinically approved iron oxide nanoparticle drug ferumoxytol in vitro results in an anti-leukaemia effect and in vivo extended overall survival in part due to the low expression of the iron export protein ferroportin.
- Vicenta Trujillo-Alonso
- , Edwin C. Pratt
- & Monica L. Guzman
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Article |
Chloroplast-selective gene delivery and expression in planta using chitosan-complexed single-walled carbon nanotube carriers
Chitosan-functionalized single-walled carbon nanotubes enable selective gene delivery to the chloroplasts of mature living plants without external mechanical aid.
- Seon-Yeong Kwak
- , Tedrick Thomas Salim Lew
- & Michael S. Strano
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Article |
Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer
Inhibiting POLR2A expression upon siRNA delivery represents a promising therapeutic strategy for triple negative breast cancers characterized by p53 inactivation.
- Jiangsheng Xu
- , Yunhua Liu
- & Xiaoming He
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Article |
Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment
Atomically dispersed gold supported by carbon dots amplifies mitochondrial oxidative stress, and leads to irreversible cell damage, inhibiting hepatocellular carcinoma in animal models.
- Ningqiang Gong
- , Xiaowei Ma
- & Xing-Jie Liang
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News & Views |
Trojan horses for immunotherapy
Responsive polymersomes enhance the action of STING-targeting cyclic dinucleotides in cancer therapy.
- Jeffrey A. Hubbell
- & Melody A. Swartz
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Article |
Self-assembled peptide–poloxamine nanoparticles enable in vitro and in vivo genome restoration for cystic fibrosis
A nanoparticle self-assembled by a multi-modular peptide and an amphiphilic poloxamine serves as a non-viral gene delivery agent for the long-term expression of CFTR in cell cultures and in animal models of cystic fibrosis.
- Shan Guan
- , Antje Munder
- & Joseph Rosenecker
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Article |
Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy
Rationally designed polymer vesicles increase cytosolic delivery of cGAMP, activating the STING pathway and increasing the immunogenicity of the tumour microenvironment in in vivo murine models of melanoma and in human metastatic melanoma tissues.
- Daniel Shae
- , Kyle W. Becker
- & John T. Wilson
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Article |
In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment
A gel with therapeutic nanoformulation that can be sprayed at the tumour resection site after surgery activates immune response in the tissue microenviroment, inhibiting tumour recurrence and potential metastasis.
- Qian Chen
- , Chao Wang
- & Zhen Gu
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News & Views |
A plug-and-play approach for malaria vaccination
A simple approach to spontaneously assemble malaria antigens into liposomes generates long-lasting, functional immune responses in mice and rabbits.
- Robert S. Oakes
- & Christopher M. Jewell
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Letter |
Bacteria photosensitized by intracellular gold nanoclusters for solar fuel production
A photosynthetic biohybrid system based on non-photosynthetic bacteria that incorporate gold nanoclusters achieves faster electron transfer and more durable solar CO2 fixation.
- Hao Zhang
- , Hao Liu
- & Peidong Yang
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Article |
Tunable thermal transport and reversible thermal conductivity switching in topologically networked bio-inspired materials
Thermal conductivity in a proteinaceous semi-crystalline material can be modulated by more than three times upon hydration and dehydration cycles.
- John A. Tomko
- , Abdon Pena-Francesch
- & Patrick E. Hopkins
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Article |
Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona
Antibody pre-adsorption on the nanocarrier surface is a mild modification strategy that preserves antibody functionality and targeting ability.
- Manuel Tonigold
- , Johanna Simon
- & Volker Mailänder
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Article |
Single-layer graphene modulates neuronal communication and augments membrane ion currents
Single-layer graphene increases neuron excitability and firing activity by influencing the distribution of potassium ions at the cellular interface.
- Niccolò Paolo Pampaloni
- , Martin Lottner
- & Denis Scaini
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Article |
Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy
Magnetic fucoidan-based nanoparticles conjugated with T-cell activators and checkpoint inhibitors can be directed to tumours via magnetic navigation for improving therapeutic efficacy and reducing systemic side effects.
- Chih-Sheng Chiang
- , Yu-Jung Lin
- & San-Yuan Chen
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Article |
Multifunctional biophotonic nanostructures inspired by the longtail glasswing butterfly for medical devices
A nanostructured membrane inspired by transparent butterfly wings is used for intraocular pressure sensing in vivo.
- Vinayak Narasimhan
- , Radwanul Hasan Siddique
- & Hyuck Choo
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Letter |
Kinesin expands and stabilizes the GDP-microtubule lattice
Kinesins, natural nanometre-scale stepper motors, can feed back on the structure and dynamics of their microtubule tracks.
- Daniel R. Peet
- , Nigel J. Burroughs
- & Robert A. Cross
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Letter |
A modular platform for targeted RNAi therapeutics
A self-assembled modular siRNA delivery platform enables the construction of a theoretically unlimited repertoire of carriers to target distinct cell surface receptors in the service of personalized medicine.
- Ranit Kedmi
- , Nuphar Veiga
- & Dan Peer
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Article |
Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression
RNA nanotechnology is utilized for directional control by altering the orientation of arrow-shaped RNAs for either ligand-display on extracellular vesicle or to regulate intracellular trafficking of siRNA or miRNA in cancer treatment.
- Fengmei Pi
- , Daniel W. Binzel
- & Peixuan Guo
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Article |
Synthetically lethal nanoparticles for treatment of endometrial cancer
The combination of paclitaxel and the antiangiogenic agent BIBF 1120, loaded into nanoparticles, induces synthetic lethality in endometrial cancers with specific mutations in the tumour suppressor p53, providing the first step towards personalized medicine for endometrial cancer.
- Kareem Ebeid
- , Xiangbing Meng
- & Aliasger K. Salem
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Article |
Bacterial resistance to silver nanoparticles and how to overcome it
Gram-negative bacteria exposed to subinhibitory concentrations of silver nanoparticles can develop resistance to their antibiotic activity due to the production of flagellin, an adhesive protein of the bacterial flagellum, which causes the aggregation of silver nanoparticles.
- Aleš Panáček
- , Libor Kvítek
- & Radek Zbořil
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Research Highlights |
Our choice from the recent literature
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Article |
Focal molography is a new method for the in situ analysis of molecular interactions in biological samples
A coherent nanopattern of molecular recognition sites, termed a mologram, enables label-free analysis of biochemical interactions in complex samples.
- Volker Gatterdam
- , Andreas Frutiger
- & Christof Fattinger
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Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions
Escorted delivery
Getting to the brain