Featured
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| Open AccessImpact of ocean acidification on crystallographic vital effect of the coral skeleton
Coral fossils can record climatic history, but teasing apart environmental signals remains a challenge. Here the authors show that crystallographic changes in coral skeletons grown under high CO2 conditions could be used as a sensitive pH proxy, enabling measurement of ocean acidification back in time.
- Ismael Coronado
- , Maoz Fine
- & Jarosław Stolarski
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Article
| Open AccessArtificial coiled coil biomineralisation protein for the synthesis of magnetic nanoparticles
Proteins have been used in the synthesis of magnetic nanoparticles but issues with aggregation limit this application. Here, the authors report on the synthesis of coiled proteins that display the active loop of the natural proteins to avoid aggregation and investigate the application in nanoparticle synthesis.
- Andrea E. Rawlings
- , Lori A. Somner
- & Sarah S. Staniland
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Article
| Open AccessTransparent and tough bulk composites inspired by nacre
Transparent materials with high strength and hardness coupled with low crack tolerance remain challenging to manufacture. Here, the authors develop a process to fabricate transparent but tough glass composites with a nacre-like architecture that slows crack propagation.
- Tommaso Magrini
- , Florian Bouville
- & André R. Studart
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| Open AccessTopologically-guided continuous protein crystallization controls bacterial surface layer self-assembly
Bacteria assemble the surface layer (S-layer), a crystalline protein coat surrounding the curved surface, using protein self-assembly. Here authors image native and purified RsaA, the S-layer protein from C. crescentus, and show that protein crystallization alone is sufficient to assemble and maintain the S-layer in vivo.
- Colin J. Comerci
- , Jonathan Herrmann
- & W. E. Moerner
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Article
| Open AccessGraphene oxide enabled long-term enzymatic transesterification in an anhydrous gas flux
Implementing enzymatic reactions in gas phase has several limitations. Here, the authors report on a method to overcome these using graphene oxide aerogels to immobilize lipase, improve stability/lifetime and investigate the mechanism for improved function.
- Weina Xu
- , Zhongwang Fu
- & Zheng Liu
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Article
| Open AccessPolymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
There is interest in developing long-lasting local anaesthetics for a range of applications. Here, the authors report on the application of tetrodotoxin conjugated to amphiphilic biodegradable polymer to reduce systemic toxicity, achieve sustained release and investigate application as a local anaesthetic.
- Chao Zhao
- , Andong Liu
- & Daniel S. Kohane
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Article
| Open AccessMicrostructure arrays of DNA using topographic control
DNA is a biological building block which has drawn much attention as a structural material for a range of applications. Here, the authors report that DNA structures can be templated using shear-induced flow and microposts for controllable DNA patterning.
- Yun Jeong Cha
- , Soon Mo Park
- & Dong Ki Yoon
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Article
| Open AccessHomochirality in biomineral suprastructures induced by assembly of single-enantiomer amino acids from a nonracemic mixture
Induction of complex homochiral architectures by chiral transformation in a mixed enantiomer system has remained largely elusive. Here, the authors report a chirality dominance effect which induces homochiral suprastructures of calcium carbonate by a mixed, heterochiral nonracemic amino acid enantiomer system.
- Wenge Jiang
- , Dimitra Athanasiadou
- & Marc D. McKee
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Article
| Open AccessAbsorbable hemostatic hydrogels comprising composites of sacrificial templates and honeycomb-like nanofibrous mats of chitosan
Sacrificial templates are used for a range of different applications. Here, the authors synthesise a hyperbranched cyclodextrin polyester template with large void spaces, which is degraded in physiological conditions, and use it to create high surface area chitosan scaffolds for haemostatic applications.
- Eric E. Leonhardt
- , Nari Kang
- & Mahmoud Elsabahy
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Article
| Open AccessDNA-templated synthesis of biomimetic cell wall for nanoencapsulation and protection of mammalian cells
The creation of protective barriers around cells is of interest for a range of applications. Here, the authors report on the creation of DNA templated alginate-polylysine biomimetic cell walls for encapsulating and shielding cells, demonstrating protection against physical assaults and immune reactions.
- Peng Shi
- , Nan Zhao
- & Yong Wang
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Article
| Open AccessPreclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration
Arthroplasty is the main clinical option for the treatment of osteoarticular lesions, but has limited efficacy. Here, the authors use a wound dressing with autologous mesenchymal stromal cells, functionalised for local BMP2 delivery, and show feasibility and safety in standardised preclinical tests in animal models, suggesting suitability for use in clinical trials.
- Laetitia Keller
- , Luc Pijnenburg
- & Nadia Benkirane-Jessel
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Article
| Open AccessA strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Uncontrollable bleeding is a major problem in surgery and after trauma. Here the authors design a photo-reactive adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute.
- Yi Hong
- , Feifei Zhou
- & Hongwei Ouyang
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Article
| Open AccessRapid evaluation of bioactive Ti-based surfaces using an in vitro titration method
In vitro testing of implant materials bioactivity is important and the current methods take time. Here, the authors report on the development of a faster titration based method for assessing the mineralization activity of materials and validate the method in vitro and in vivo using titanium surfaces.
- Weitian Zhao
- , David Michalik
- & Paul Bowen
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Article
| Open AccessCheckpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
Immunotherapy for the treatment of cancer can be complicated by side effects and poor efficacy. Here, the authors use a nanoparticle-based approach in combination with a TLR7 agonist and sonodynamic therapy, and find that when used together with anti-PD-L1, tumour formation and metastases are impacted.
- Wenwen Yue
- , Liang Chen
- & Yu Chen
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| Open AccessA tightly-bonded and flexible mesoporous zeolite-cotton hybrid hemostat
Zeolites have attracted attention and have been applied as haemostatic agents; however, there are issues associated with released zeolite powder. Here, the authors report on the growth of zeolites on cotton fibres with high stability and haemostatic ability.
- Lisha Yu
- , Xiaoqiang Shang
- & Jie Fan
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Article
| Open AccessIn vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
Nanoparticle delivery of siRNA has problems with penetration and off target accumulation. Here, the authors report on the development of Y-shaped block catiomers which dynamically wrap around siRNA; demonstrate increased circulation times and delivery into hard to reach brain and pancreas tumour models.
- Sumiyo Watanabe
- , Kotaro Hayashi
- & Kazunori Kataoka
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Article
| Open AccessArtificial cell membrane binding thrombin constructs drive in situ fibrin hydrogel formation
The incorporation of cells into tissue engineering scaffolds can be a major challenge. Here, the authors report on anchoring thrombin to cell membranes for the in situ formation of fibrin scaffolds around the modified cells, demonstrate scaffold formation in vitro and show cell survival in vivo.
- Robert C. Deller
- , Thomas Richardson
- & Adam W. Perriman
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Article
| Open AccessEnzymatic synthesis of lignin derivable pyridine based polyesters for the substitution of petroleum derived plastics
The increasing concern of global plastic pollution has led to an increase in the production and characterization of bio-based and biodegradable alternatives. Here the authors show the synthesis of a series of fully bio-based alternatives based on 2,4-, 2,5-, and 2,6- pyridinedicarboxylic acids, via enzymatic catalysis.
- Alessandro Pellis
- , James W. Comerford
- & Thomas J. Farmer
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Article
| Open AccessImmunoregulation of macrophages by dynamic ligand presentation via ligand–cation coordination
Control of macrophage adhesion and phenotype is important to biomaterial applications. Here, the authors report on the use of bisphosphonate coated gold nanoparticles by magnesium coordination for the controlled adhesion and polarisation of macrophages in vitro and in vivo and controlled cell release.
- Heemin Kang
- , Boguang Yang
- & Liming Bian
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Article
| Open AccessPerovskite nickelates as bio-electronic interfaces
Functional materials that act as bio-sensing media when interfaced with complex bio-matter are attractive for health sciences and bio-engineering. Here, the authors report room temperature enzyme-mediated spontaneous hydrogen transfer between a perovskite quantum material and glucose reactions.
- Hai-Tian Zhang
- , Fan Zuo
- & Shriram Ramanathan
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| Open AccessDirected self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation
There is interest in the development of drug-based hydrogels for responsive sustained drug release. Here, the authors report on the self-assembly of natural small molecule, rhein, into hydrogels and the application of the hydrogels as stable controlled release agents for neuro-inflammatory therapy
- Jun Zheng
- , Rong Fan
- & Yang Wang
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Article
| Open AccessNucleobase pairing and photodimerization in a biologically derived metal-organic framework nanoreactor
Metal-organic frameworks have shown promise as nanoreactors, facilitating the synthesis of molecules that are otherwise difficult to isolate. Here, the authors design a framework featuring unobstructed adenine linkers to which thymine molecules can base-pair, allowing for thymine dimerization in the pores upon UV irradiation.
- Samantha L. Anderson
- , Peter G. Boyd
- & Kyriakos C. Stylianou
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Article
| Open AccessPerfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy
Hypoxia-based agents need permeable and hypoxic intratumour environment to be effective. Here, the authors show that perfluorocarbon nanoparticles promote increased permeability and sustained hypoxia to improve accumulation of hypoxia-based agents, and inhibit intratumour oxygen reperfusion.
- Wenguang Wang
- , Yuhao Cheng
- & Jinhui Wu
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Article
| Open AccessPlant-inspired adhesive and tough hydrogel based on Ag-Lignin nanoparticles-triggered dynamic redox catechol chemistry
Biomimetic catechol-based adhesives have attracted significant interest but can lose adhesion due to excessive oxidation. Here, the authors report on the addition of silver-Lignin nanoparticles as a dynamic catechol redox system to maintain catechol/quinone balance, making a reusable, antibacterial bioadhesive.
- Donglin Gan
- , Wensi Xing
- & Xiong Lu
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Article
| Open AccessA study of the extraordinarily strong and tough silk produced by bagworms
Spider silk is widely studied for its structural properties; however, other creatures produce silk that could be of interest. Here, the authors study the properties and structure of Bagworm silk and report it as being extraordinarily strong and tough compared to other known silks.
- Taiyo Yoshioka
- , Takuya Tsubota
- & Tsunenori Kameda
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Article
| Open AccessLabel-free detection of conformational changes in switchable DNA nanostructures with microwave microfluidics
Methods to study conformational changes in biomolecules are limited in resolution and require labelling or other modifications of target analytes. Here the authors present a label-free, microwave microfluidic approach to detect conformational changes of DNA nanostructures based on ionic conductivity.
- Angela C. Stelson
- , Minghui Liu
- & James C. Booth
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Article
| Open AccessFramework nucleic acids as programmable carrier for transdermal drug delivery
DNA nanostructures hold great promise for drug delivery, but systemic administration is problematic. Here, the authors demonstrate that framework nucleic acids (FNAs) improve drug accumulation in tumours in topical application and that penetration depth is controllable through adjusting FNA size.
- Christian Wiraja
- , Ying Zhu
- & Chenjie Xu
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| Open AccessIntracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions
Cell membrane interface is mostly studied using synthetic bilayers and reconstituted cell membranes. Here the authors present a new cell fixation method in which the cytoskeleton is replaced by a synthetic hydrogel polymer network assembled inside the cell, thereby preserving the fluid membrane properties after cell death.
- Jung-Chen Lin
- , Chen-Ying Chien
- & Che-Ming J. Hu
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Article
| Open AccessDynamic pigmentary and structural coloration within cephalopod chromatophore organs
Chromatophores in cephalopod skin are known for fast changes in coloration due to light-scattering pigment granules. Here, authors demonstrate structural coloration facilitated by reflectin in sheath cells and offer insights into the interplay between structural and pigmentary coloration elements.
- Thomas L. Williams
- , Stephen L. Senft
- & Leila F. Deravi
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| Open AccessBio-inspired nitric-oxide-driven nanomotor
Depletion of propellant in chemical-fuel-driven nanomotors is a limiting factor in device design and application. Here, the authors create a nitric-oxide-generating nanoparticle and explore cellular uptake and application of the nanomotors in nitric oxide treatments.
- Mimi Wan
- , Huan Chen
- & Jian Shen
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Article
| Open AccessPhotosynthetic apparatus of Rhodobacter sphaeroides exhibits prolonged charge storage
Photosynthetic proteins are used to harvest solar energy in bio-photovoltaics, but are typically not investigated for charge storage. Here the authors report prolonged charge storage in multilayers of photoproteins as well as a proof-of-principle biophotonic power cell with purple bacterial photoproteins.
- Sai Kishore Ravi
- , Piper Rawding
- & Swee Ching Tan
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Article
| Open AccessIntravenous treatment of choroidal neovascularization by photo-targeted nanoparticles
Current treatments of wet age-related macular degeneration require repeated injections of active drugs into the vitreous. Here Wang et al. develop nanoparticles that when injected intravenously can be targeted to the eye by irradiation with blue light, allowing local and enhanced drug release in the back of the eye, and providing an alternative to current delivery strategies.
- Yanfei Wang
- , Chi-Hsiu Liu
- & Daniel S. Kohane
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Article
| Open AccessTear resistance of soft collagenous tissues
Defect tolerance is important in order to ensure the mechanical integrity of synthetic materials and biological tissues. Here the authors demonstrate that toughening mechanisms provide soft collagenous tissues with high defect tolerance, with important implications for biomedical applications.
- Kevin Bircher
- , Manuel Zündel
- & Edoardo Mazza
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Article
| Open AccessAmine-responsive cellulose-based ratiometric fluorescent materials for real-time and visual detection of shrimp and crab freshness
Simple, fast, and accurate detection of food freshness has great significance to food safety and business. Here, the authors develop cellulose-based ratiometric fluorescent materials with superior amine-response, which can be used for visual monitoring the freshness of shrimp and crab.
- Ruonan Jia
- , Weiguo Tian
- & Jun Zhang
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| Open AccessX-ray nanotomography of coccolithophores reveals that coccolith mass and segment number correlate with grid size
Coccolithophores are one of the most abundant phytoplankton and calcifying organisms, well-known to produce intricate calcareous exoskeletons made of coccoliths. Here the authors show, by using X-ray nanotomography, the dependence of the grid size on the calcite nucleation site number and on the mass of coccoliths.
- T. Beuvier
- , I. Probert
- & A. Gibaud
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Article
| Open AccessPatterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
Heart grafts need good vascularization to survive. Here, the authors engineer perfusable constructs of human embryonic stem cell-derived endothelial cells seeded in collagen matrix in patterned microchannels that form anastomosed vessels in vitro and have increased coronary vascular perfusion on transplantation in rats.
- Meredith A. Redd
- , Nicole Zeinstra
- & Ying Zheng
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Article
| Open AccessVolume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
For mesenchymal stem cells (MSCs), matrix remodeling is associated with enhanced osteogenic differentiation. Here authors find that MSCs in viscoelastic hydrogels exhibit volume expansion during cell spreading, and greater volume expansion is associated with enhanced osteogenesis.
- Hong-pyo Lee
- , Ryan Stowers
- & Ovijit Chaudhuri
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Article
| Open AccessControlling the fluorescence and room-temperature phosphorescence behaviour of carbon nanodots with inorganic crystalline nanocomposites
Materials exhibiting room temperature phosphorescence (RTP) with short afterglow are desirable for bio-medical applications. Here the authors synthesise a library of compounds with tunable RTP properties, embedding carbon nanodots in non-toxic alkaline-earth carbonate, sulphate and oxalate hosts.
- David C. Green
- , Mark A. Holden
- & Fiona C. Meldrum
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Article
| Open AccessDefect engineered bioactive transition metals dichalcogenides quantum dots
Transition metal dichalcogenide (TMD) quantum dots (QDs) have promising electronic properties which might be further tailorable by defect engineering. Here the authors describe a room temperature aqueous based synthesis of TMD QDs with controlled defect concentration, and demonstrate the correlation between defect concentration and biomedical activity.
- Xianguang Ding
- , Fei Peng
- & David Tai Leong
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Article
| Open AccessSelf-assembled membrane composed of amyloid-like proteins for efficient size-selective molecular separation and dialysis
Membrane separation is important for a range of industrial and medical applications. Here, the authors report on the formation of self-assembled protein membranes for size selective separation and demonstrate application in the separation of dyes, nanoparticles and in hemodialysis.
- Facui Yang
- , Fei Tao
- & Peng Yang
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Matters Arising
| Open AccessCharacterizing coral skeleton mineralogy with Raman spectroscopy
- Thomas M. DeCarlo
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Article
| Open AccessClosed-loop functional optogenetic stimulation
Optogenetics is a promising alternative approach for restoration of neuromuscular function. Here the authors establish a closed-loop functional optogenetic stimulation for the control of limb joint angle in murine models, which demonstrates improved control and less fatigue than electrical stimulation systems.
- Shriya S. Srinivasan
- , Benjamin E. Maimon
- & Hugh M. Herr
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Article
| Open AccessNanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between β-sheets
Peptide self-assembly is a hierarchical process which includes forming β-sheets but the formation of high ordered structures remains largely unexplored. Here the authors report on a super-secondary structural template, based on well-defined hydrogen bonds by rational design and assembly of short peptides
- Meng Wang
- , Jiqian Wang
- & Hai Xu
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Article
| Open AccessA biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis
Photodynamic therapy is usually ineffective against deeply seated metastatic tumors due to poor penetration of the excitation light. Here, the authors design a biomimetic nanoreactor which can convert nutriment glucose into toxic singlet oxygen via chemiluminescence resonance energy transfer with no light excitation and demonstrate its high efficacy in a mouse lung metastatic model.
- Zhengze Yu
- , Ping Zhou
- & Bo Tang
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Article
| Open AccessCommunication and quorum sensing in non-living mimics of eukaryotic cells
Cells communicate through chemical and mechanical signals but emulating these in non-living mimics has been challenging. Here the authors present a porous mimic with a DNA-hydrogel ‘nucleus’ that can communicate through diffusive protein signals.
- Henrike Niederholtmeyer
- , Cynthia Chaggan
- & Neal K. Devaraj
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Article
| Open AccessEntropy production rate is maximized in non-contractile actomyosin
Myosin motors drive the actin cytoskeleton out-of-equilibrium, but the role of myosin-driven active stresses in the accumulation and dissipation of mechanical work is unclear. Here, the authors synthesize an actomyosin material and find that the rate of entropy production increases non-monotonically with increasing accumulation of active stresses.
- Daniel S. Seara
- , Vikrant Yadav
- & Michael P. Murrell
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Article
| Open AccessMR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma
Imaging tracking of the migration of cell-based drug delivery systems are needed for expanding their clinical application for glioma. Here they report inflammation activatable engineered neutrophils containing doxorubicin-loaded magnetic mesoporous silica nanoparticles to image and actively target brain tumors after resection.
- Meiying Wu
- , Haixian Zhang
- & Hairong Zheng
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Article
| Open AccessSelf-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery
Treatment for eye injuries and diseases is most efficient when delivered directly into the eye. Here, the authors developed a patient-friendly eye patch equipped with an array of detachable microneedles, through which drugs can be delivered through the cornea for an extended period of time.
- Aung Than
- , Chenghao Liu
- & Peng Chen
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Article
| Open AccessProgramming molecular topologies from single-stranded nucleic acids
Designing nucleic acid-based nanostructures with knots remains challenging. Here the authors present a general strategy to design and construct highly knotted 2D and 3D nanostructures from single-stranded DNA or RNA
- Xiaodong Qi
- , Fei Zhang
- & Hao Yan