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Proteomic definition of the telomeric PARylome combined with genetic and histone H3.3 deposition assays at telomeres reveals that PAR-regulated HIRA activity compensates for loss of ATRX in ALT cells.
A new X-ray crystal structure and supporting biochemical analyses of the human cardiac calsequestrin polymer reveal the basis of filament assembly and map disease-associated mutations to the multimerization interface.
The solid-state NMR structure of an amyloid fiber formed by human hormone β-endorphin reveals a protonated Glu8 in the fibrillar core. Under neutral conditions, deprotonation of Glu8 would contribute to fibril disassembly and hormone peptide release.
BAX and BAK oligomerize to mediate mitochondrial membrane permeabilization during apoptosis. A recent structure of the core domain of active BAK dimers with bound phospholipid molecules reveals a new bridging mechanism by which lipids drive BAX and BAK oligomerization and membrane pore formation.
Primary cilia are isolated from monolayers of mammalian cells in culture for cryo-ET analyses, revealing new features as well as how they differ from motile cilia.
The effects of four antibodies on the aggregation pathway of Aβ are examined via an in-depth kinetics approach, revealing the specific molecular steps affected by each antibody.
Atomic force microscopy imaging of yeast condensin indicates that condensin may extrude DNA by switching conformation between open O and collapsed B shapes, indicative of a type of scrunching model.
In situ structures of the spirochete flagellar motor by cryo-ET reveal two distinct modes of interactions between the rotor ring and stator units. Together with new cryo-EM structures of the isolated stator units, this work provides insights into the mechanisms of torque generation and directional switch.
Design of a bicistronic biosensor allows simultaneous quantification of cap- and IRES-mediated translation under normal and stress conditions in living mammalian cells.
Live-cell imaging of tagged genomic loci reveals clusters of distal enhancers in close proximity to target genes, creating a nanoenvironment wherein site-specifically recruited enhancer-associated regulatory factors activate transcription.
Crystal structures of BAK core domain dimers suggest a mechanism by which lipids contribute to the oligomerization of BAK, which is essential for BAK-mediated permeabilization of the mitochondrial outer membrane.
DUOX1 is an NADPH oxidase involved in thyroid hormone production and innate host defense. Cryo-EM structures of murine DUOX1 bound to maturation factor DUOXA1 provide insights into regulation and activation of this enzyme.
Cryo-EM structures of the entire mammalian F1Fo ATPase reveal several new features and details on the proton translocation pathway and suggest a model for the opening of the permeability transition pore.
Analysis of co-occurring chromatin interactions using multi-contact 3C and polymer simulations shows that, during interphase, entanglements between chromosomes and chromosomal domains are rare.
Cryo-EM structures of diabetes-related amyloids formed by wild-type human amylin (IAPP) and its S20G variant reveal a mode for surface-templated fibril growth.
Cryo-EM structures of Cas12i in multiple functional states provide insights that might facilitate the manipulation of this type V CRISPR-Cas endonuclease for genome editing applications.