BAX and BAK oligomerize to mediate mitochondrial membrane permeabilization during apoptosis. A recent structure of the core domain of active BAK dimers with bound phospholipid molecules reveals a new bridging mechanism by which lipids drive BAX and BAK oligomerization and membrane pore formation.
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Flores-Romero, H., García-Sáez, A.J. Lipids glue BAK dimers together. Nat Struct Mol Biol 27, 1003–1004 (2020). https://doi.org/10.1038/s41594-020-00516-y
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DOI: https://doi.org/10.1038/s41594-020-00516-y
