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Methylation of the lysine demethylase KDM1A and the recognition of this modification by the chromodomain helicase CHD1 control androgen-dependent gene transcription and TMPRSS2-ERG gene fusion, a common translocation event in prostate cancer.
Methylation of adenosine within mRNA coding regions delays tRNA accommodation during translation and thus changes translation dynamics, which might influence protein folding.
The adhesion molecule Afadin acts as a scaffold coordinating the cortical assembly of the cellular machinery that orients the mitotic spindle and drives planar cell division.
Release of neurotransmitters occurs by opening of a fusion pore in a manner thought to be mediated by SNARE proteins, but whether the fusion pore is a lipidic or a proteinaceous structure is controversial. A new study using very small nanodiscs shows that it is both.
Rea1 is an ATPase related to dynein motor proteins that has been implicated in the biogenesis of the 60S ribosomal subunit. A new cryo-EM study vividly demonstrates the power of structural methods, deciphering the role of Rea1 in monitoring key pre-60S maturation steps before the acquisition of export competence in budding yeast.
A comprehensive review of the discovery and molecular dissection of the eukaryotic ribosome-associated quality-control pathway for degradation of nascent proteins arising from interrupted translation.
Crystal structures of human HSF1 DNA-binding domain in complex with DNA and of the coiled-coil domain from a fungal ortholog provide insight into the mode of interaction of this transcription factor with DNA.
Crystal structures of human HSF2 DNA-binding domain bound to DNA, along with biochemical and cellular analyses, offer insight into potential regulatory interactions of this transcription factor.