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Ribosome-associated protein quality control

Nature Structural & Molecular Biology volume 23, pages 7–15 (2016)Cite this article

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Abstract

Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA, insufficient availability of charged tRNAs and genetic errors. All organisms have evolved mechanisms to recognize stalled ribosomes and initiate pathways for recycling, quality control and stress signaling. Here we review the discovery and molecular dissection of the eukaryotic ribosome-associated quality-control pathway for degradation of nascent polypeptides arising from interrupted translation.

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Figure 1: Causes of aberrant translation elongation.
Figure 2: Primary steps and factors of ribosome-associated quality control.
Figure 3: Working model for recognition of a stalled ribosome by recycling factors.
Figure 4: Steps of RQC assembly on 60S–peptidyl-tRNA complexes.
Figure 5: CAT-tail formation by Rqc2p.

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Acknowledgements

We thank S. Shao for comments on this manuscript and A. Frost and P. Shen for help with figure preparation. This work was supported by the UK Medical Research Council (MC_UP_A022_1007 to R.S.H.), Stanford University (O.B.) and the US National Institutes of Health (1R01GM115968-01 to O.B.).

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  1. Department of Biochemistry, Stanford University, Stanford, California, USA

    Onn Brandman

  2. Medical Research Council Laboratory of Molecular Biology, Cambridge, UK

    Ramanujan S Hegde

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Correspondence to Onn Brandman or Ramanujan S Hegde.

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Brandman, O., Hegde, R. Ribosome-associated protein quality control. Nat Struct Mol Biol 23, 7–15 (2016). https://doi.org/10.1038/nsmb.3147

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