Release of neurotransmitters occurs by opening of a fusion pore in a manner thought to be mediated by SNARE proteins, but whether the fusion pore is a lipidic or a proteinaceous structure is controversial. A new study using very small nanodiscs shows that it is both.
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Acknowledgements
Support by the European Research Council (ERC) grant ADG 322699 (M.L.) and US National Institutes of Health (NIH) grant R21NS088253 (M.L.) is gratefully acknowledged.
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Sharma, S., Lindau, M. The mystery of the fusion pore. Nat Struct Mol Biol 23, 5–6 (2016). https://doi.org/10.1038/nsmb.3157
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DOI: https://doi.org/10.1038/nsmb.3157
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