Mechanisms of RNA processing and splicing
In this issue, we feature studies on RNA processing, including mechanisms of mRNA splicing, biogenesis of the splicing machinery, mRNA decoding by the ribosome, and mRNA deadenylation for degradation.
In this issue, we feature studies on RNA processing, including mechanisms of mRNA splicing, biogenesis of the splicing machinery, mRNA decoding by the ribosome, and mRNA deadenylation for degradation.
NAD(H) redox homeostasis has a fundamental role in cellular metabolism. We screened for potential modulators of NAD(H) using a genome-scale RNA interference (RNAi) approach combined with SoNar, a high-performance sensor that is sensitive to the redox state of NAD(H). Our analysis identified HES4 as a negative regulator of the NADH/NAD+ ratio that influences pyrimidine biosynthesis and exerts a potent oncogenic effect.