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New research demonstrates that the amino acid composition of the hypervariable CDR3 region of T cell receptors is influenced by the presence of HLA risk alleles for autoimmune disease.
New research demonstrates that a hydrogel-based miRNA delivery system might have therapeutic potential to treat osteoarthritis by targeting chondrocyte senescence.
New evidence implicates necroptosis in muscle fibre damage in idiopathic inflammatory myopathies, but is it too soon to suggest that interfering with this cell-death pathway could offer a novel therapeutic strategy?
New classification criteria for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis endorsed by ACR and EULAR reflect important developments in the field since the 1990 criteria were published, including bringing ANCA testing to the fore.
In this Review, the authors discuss a comprehensive mechanistic concept of psoriatic arthritis, including discussion of the genetic, biomechanical, metabolic and microbial factors that contribute to the development of the disease as well as its manifestations and consequences.
In this Review, the authors discuss the challenges of multimorbidity, polypharmacy and geriatric syndromes in older patients with inflammatory rheumatic diseases. They note that individually tailored interventions are needed in this patient group in order to preserve patient independence and overall functioning.
Sphingosine 1-phosphate has essential roles in vascular barrier function, lymphocyte trafficking and differentiation, and inflammatory response in autoimmune rheumatic diseases; modulation of sphingosine 1-phosphate signalling is a potential therapeutic approach in systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis.
Intervertebral disc calcification is an often overlooked phenotype that can have considerable clinical consequences. In this article, the authors aim to raise awareness of intervertebral disc calcification and discuss its implications for the management and prognosis of degenerative spinal changes.
