Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 17 Issue 11, November 2021

COVER: Inspired by the Review on p651.

Cover design: S.Harris

Research Highlights

Top of page ⤴

News & Views

  • New evidence has emerged that DNA can bind to cell surface HLA class II molecules. If true, this surprising interaction could lead to T cell and B cell activation by DNA, and surface DNA could also provide a target for cell killing by anti-DNA antibodies in systemic lupus erythematosus.

    • David S. Pisetsky
    News & Views
  • The ACR have published their first guideline for the management of large vessel vasculitis, which covers giant cell arteritis and Takayasu arteritis. The new guideline differs from the current EULAR recommendations on some important points, but do these different views actually affect patient care?

    • Bernhard Hellmich
    • Frank Buttgereit
    News & Views
Top of page ⤴


  • Analysis of the microcirculation is useful in the differential diagnosis of primary and secondary Raynaud phenomenon and in the diagnosis and monitoring of several rheumatic diseases, including systemic sclerosis. This Review provides an overview of techniques for microvascular analysis.

    • Maurizio Cutolo
    • Vanessa Smith
    Review Article
  • Interferon-γ (IFNγ) is important in innate and adaptive immunity and its overproduction is also implicated in hyperinflammation. Here, De Benedetti and colleagues discuss the evidence for a pathogenetic role of IFNγ in hyperinflammatory diseases, the search for IFNγ biomarkers, and the results of clinical trials of IFNγ-neutralizing therapeutics.

    • Fabrizio De Benedetti
    • Giusi Prencipe
    • Alexei A. Grom
    Review Article
  • Non-coding RNAs such as microRNAs, long non-coding RNAs and circular RNAs regulate signalling pathways that are important in joint development, homeostasis and disease. A better understanding of the non-coding RNA interactome could lead to new therapies for joint diseases.

    • Shabana A. Ali
    • Mandy J. Peffers
    • Mohit Kapoor
    Review Article
Top of page ⤴


Quick links