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The ability to resolve, rather than suppress, inflammation could enable new possibilities for the treatment of chronic diseases such as rheumatoid arthritis. Knowing more about the function of immune-regulatory cytokines is the first step towards realizing their therapeutic potential.
A variety of comorbidities of gout exist, but most of these associations are not causally linked. Mendelian randomization analysis of genome-wide association study data now suggests that iron overload might increase serum uric acid levels and hence the risk of gout flares.
Our ability to interrogate the genetic and epigenetic processes that underpin disease are advancing rapidly. In this Review, Radstake and colleagues highlight insights gained into the pathogenesis of systemic sclerosis from the past 4 years of genetic and epigenetic research.
Hand osteoarthritis (OA) is a heterogeneous and prevalent condition involving multiple joints. In this Review, the authors provide an update on the epidemiology, presentation and burden of hand OA, as well as on advances in imaging techniques, disease management and pathogenesis.
Current guidelines for the treatment of osteoarthritis involve exercise and lifestyle modifications as well as pharmaceutical therapeutics for effective pain management. Is this message reaching patients, and are they exercising enough?
Both spondyloarthritis and uveitis are associated with HLA-B27 positivity. This Review discusses this overlap and how the intestinal microbiome and dysbiosis might contribute to the development of both diseases.
Seropositive RA can present with two different types of autoantibodies that have distinct features: anti-citrullinated protein antibodies (ACPAs) and rheumatoid factors (RFs). With a single-cell approach, researchers provide evidence that the underlying B cell subsets of these autoantibody specificities develop in parallel by different mechanisms.
The IL-23–IL-17 signalling pathway has paradoxical effects on bone remodelling in psoriatic arthritis and ankylosing spondylitis. In this Review, Gravallese and Schett examine the evidence for and outline the reasons behind this paradox.
Adult-onset Still’s disease (AoSD) is not easily diagnosed, and treatment options are limited. This Review provides an overview of the disease and its pathogenesis, clinical trial results, therapeutic options and a plan to diagnose and clinically manage these patients.