Advances in neuroimaging research have enabled the development of predictive models that integrate information from multiple brain systems. Here, Perovnik, Rus and colleagues discuss the detection and validation of neurodegenerative disease-specific functional brain networks and consider their relationship to pathological processes and disease-related genotypes.

Amyotrophic lateral sclerosis (ALS) is a devastating, incurable disease characterized by progressive loss of upper and lower motor neurons. Here, the authors describe the current landscape of genetic therapies for ALS and discuss new opportunities for gene replacement therapy, focusing on loss-of-function mutations.

Technological advances over the past decade have made precision genetic diagnosis available to many patients. The findings of a new study demonstrate that genetic diagnosis in epilepsy can lead to changes in clinical management that manifest as positive outcomes for the patient. The results herald a new era in which precision diagnosis will lead to precision medicine.

A new study used a metagenomic approach to survey the entire gut microbiome in people with Parkinson disease and identified specific changes that could be linked to the pathogenesis of the disease.

Normalizing aberrant calcium release from the endoplasmic reticulum restores lysosome function in AD models.

New findings suggest that neuroinflammation disrupts brain networks in Alzheimer disease independently of amyloid-β deposition.