Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Spontaneous activity in the developing auditory system is maintained by a homeostatic mechanism and is important for cochlear neuron subtype specification.
Mice receiving autoantibodies against the GluA2 AMPA receptor subunit from individuals with autoimmune encephalitis exhibit changes in AMPA receptor subunit composition and impaired synaptic plasticity and memory.
Rodent models are extensively used to investigate the pathophysiology of Alzheimer disease. In this Review, Götz, Bodea and Goedert critically examine the approaches that have been adopted to generate rodent Alzheimer disease models and touch on some of the lessons that have been learned from their use.
Cognitive impairment is a key feature of multiple sclerosis (MS). Di Filippo and colleagues provide an overview of the cognitive domains and brain regions that are affected in MS, with a focus on potential hippocampal mechanisms underlying learning and memory deficits in this disease.
Inflammasomes are pro-inflammatory protein complexes that become activated in a range of neurodegenerative conditions. In this review, Heneka and colleagues discuss recent findings that provide fresh insights on the role of inflammasomes across cell types and disease states in the brain.
Technological advances have allowed the molecular ‘signatures’ of microglia to be characterized, providing insight into their roles in CNS function. Weiner and Butovsky discuss the plasticity of these signatures in health and disease and consider the mechanisms underlying their establishment, maintenance and regulation.
