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  • One of the long-term sequelae associated with SARS-CoV-2 infection is ‘brain fog’, which is shown in this study to be linked to systemic inflammation and leakiness of the blood–brain barrier.

    • Sian Lewis
    Research Highlight
  • Neurons in the mouse subiculum encode concave and convex geometrical environmental features.

    • Katherine Whalley
    Research Highlight
  • Innate fear-like responses are thought to involve the amygdala, but here a tetra-synaptic pathway is identified that mediates odour-evoked innate fear in mice.

    • Sian Lewis
    Research Highlight
  • Populations of neurons in the mouse hippocampus use distinct representational strategies to encode familiarity and episodic social memory.

    • Katherine Whalley
    Research Highlight
  • Increased levels of matrix metalloproteinase 8, expressed by circulating myeloid cells, may have a role in stress-induced changes in social behaviour in mice.

    • Darran Yates
    Research Highlight
  • Blood pressure pulsations modulate the activity of neurons in the rodent olfactory bulb via the mechanosensitive ion channel PIEZO2

    • Katherine Whalley
    Research Highlight
  • In this Journal Club, Valeria Della-Maggiore highlights a 2017 paper that provided key evidence for a role for the hippocampus in motor skill learning

    • Valeria Della-Maggiore
    Journal Club
  • In mice, a subset of neurons in the dorsomedial hypothalamus control sympathetic nervous system signalling to adipose tissue and are dysregulated with age; activating these neurons prolongs lifespan and slows the decline in physical activity associated with ageing.

    • Joseph Willson
    Research Highlight
  • A study analyses the nanotopography of presynaptic calcium channels and release sensors and the degree of their coupling during maturation of an inhibitory synapse.

    • Lisa Heinke
    Research Highlight
  • Around 10% of individuals with frontotemporal lobar dementia have amyloid filament inclusions that lack tau and TDP-43 and were thought to contain the protein FUS, but are found instead to contain the FUS homologue TAF15.

    • Sian Lewis
    Research Highlight
  • Cytoplasmic mislocalization of TDP-43 in neurodegenerative disease affects mRNA maturation and protein levels of stathmin-2, leading to a reduction in axon diameter and tearing of outer myelin layers and thereby disrupting neuronal function.

    • Lisa Heinke
    Research Highlight
  • A study in mice identifies formin 2 as a regulator of axon regeneration and a potential target for promoting nerve repair after peripheral nerve injury.

    • Darran Yates
    Research Highlight
  • A mark test of self-recognition in mice reveals that self-responding ventral CA1 neurons underlie mirror-induced self-directed behaviour and are shaped by social experience with conspecifics.

    • Jake Rogers
    Research Highlight
  • A small population of neurons in the mouse brainstem coordinate sound production and volume control during vocalizations.

    • Katherine Whalley
    Research Highlight
  • A study in mice helps to resolve a debate surrounding striatal DA dynamics and reward benefit or cost and also reveals motivation and transient striatal DA release have a bidirectional causal relationship.

    • Jake Rogers
    Research Highlight
  • In mice, specific pools of adult neural stem cells are recruited during pregnancy to support postpartum maternal behaviour.

    • Katherine Whalley
    Research Highlight
  • Ongoing systemic and neurocognitive impairments that continue in a subset of individuals after infection with SARS-CoV-2 infection are found to be associated with reduced serotonin levels.

    • Sian Lewis
    Research Highlight