Recent technological advances have enabled ever more detailed characterizations of neuronal subtypes. Here, immunohistochemistry and unbiased single-nucleus RNA sequencing was used to identify several human cortical GABAergic neuronal subtypes that possess distinct molecular signatures and transcriptomes. One notable subtype had ‘rosehip’-like axonal boutons and inhibited backpropagating action potentials in pyramidal neuron dendrites; these neurons are thus likely to be involved in local regulation of dendritic computation.
References
Original article
Boldog, E. et al. Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type. Nat. Neurosci. 21, 1185–1195 (2018)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lewis, S. Novel inhibition. Nat Rev Neurosci 19, 581 (2018). https://doi.org/10.1038/s41583-018-0064-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41583-018-0064-6