Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The combined actions of immune cells, vascular cells and neurons mediate a 'neuroinflammatory' response to pathogens, trauma and degeneration in the CNS. Here, Xanthos and Sandkühler show that similar responses can be evoked by neural activity and describe the physiological and pathological roles of this 'neurogenic neuroinflammation'.
Neural progenitor cell (NPC) profileration in mice is associated with oscillating patterns of expression of several transcription factors, whereas NPC differentiation is associated with the sustained, dominant expression of particular transcription factors.
During development, individual neural progenitors give rise to a series of distinct types of neural progeny that are produced in a specific temporal order. Kohwi and Doe discuss how temporal neural patterning is dictated by extrinsic and intrinsic cues known as temporal-identity factors, as well as by changes in progenitor competence in response to these factors.
Newly generated glutamatergic synapses lack functional AMPA receptor-mediated transmission. Depending on the type of activity that these newborn AMPA-silent synapses are exposed to, they are eventually either eliminated or stabilized. Hanseet al. review recent studies on the abnormal generation of AMPA-silent synapses and on premature or delayed unsilencing that highlight their role in brain pathology.
