Mice lacking the synaptic plasticity-mediating protein calcineurin in their forebrain have behavioural and cognitive abnormalities equivalent to those found in patients with schizophrenia; however, the underlying mechanism is unclear. Hippocampal sharp wave ripple (SWR) events are associated with memory consolidation, and calcineurin-knockout mice were found to exhibit SWRs during post-experience rest periods and lacked the sequential reactivation of hippocampal place cells that normally occurs during SWR events. These data suggest a potential mechanism underlying some of the behavioural alterations seen in schizophrenia.
References
Suh, J. et al. Impaired hippocampal ripple-associated replay in a mouse model of schizophrenia. Neuron 80, 484–493 (2013)
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Lewis, S. Creating ripples. Nat Rev Neurosci 14, 816 (2013). https://doi.org/10.1038/nrn3633
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DOI: https://doi.org/10.1038/nrn3633