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The human microbiome has a crucial role in global health, with implications for achieving the Sustainable Development Goals (SDGs). Understanding and harnessing the potential of the microbiome, while recognizing its link to the global ecosystem, can drive innovative strategies for improved public health, and promote sustainable development.
African microbiomes are much neglected and previous studies have disproportionately focused on the Global North. Africa harbours substantial genetic diversity in terms of its ecosystems, humans and animals. In this Comment, we highlight the lack of information regarding microbiome datasets from Africa and propose mechanisms for increasing microbiome research in Africa.
In this study, Fidelle et al. show that recolonization of the gut by Enterocloster spp. after antibiotic treatment compromises the anticancer effect of immune checkpoint inhibitor therapy.
In this study, Catchpole et al. identify the first self-transmissible conjugative plasmid in the euryarchaeon Thermococcus sp. 33-3 and use it to genetically modify diverse hyperthermophilic archaea.
In this study, Vidakovic et al. show that during infection Vibrio cholerae forms biofilms on the surface of human immune cells to kill them and then disperses.
In this Review, Hsu and Schnabl examine the role of the gut microbiota in liver and intestine function, and how gut microorganisms contribute to liver diseases, and explore different microbiota-based strategies for the treatment of liver disease.
This study shows that healthy individuals are reservoirs for genotypically and phenotypically diverse Candida albicans strains that retain their capacity to cause disease.
This Genome Watch highlights the recent developments of prokaryotic nomenclature leading to the coexistence of two parallel prokaryotic nomenclatural codes.
In this study, Liu et al. demonstrate that the T7SS of the rhizobacterium Bacillus velezensis SQR9 and its effector protein YukE cause iron leakage in plant roots to support root colonization.
In this Review, Stride and co-workers discuss emerging drug delivery strategies that are explored in antibiofilm therapy to improve the clinical efficacy of antibiofilm agents, highlighting their current limitations and future prospects.
This study reports a bacterial antiphage protein that contains a NACHT domain, which is also found in metazoan proteins that mediate immunity and inflammation.
In this Review, Wang, Gao and Aksoy delve into the influence of microbiota on vector physiology and competence, provide an overview of the common and unique characteristics of microbiota in major disease vector systems and examine the potential applications of manipulating vector microbiota for vector control purposes.
This study reports the identification of an inhibitor of a Toxoplasma gondii myosin motor protein that could be exploited to prevent or treat infections with T. gondii and other apicomplexan parasites.
In this Review, Martínez, Hernando-Amado and colleagues explore how eco-evolutionary-based approaches can aid in the design of successful antibiotic therapies, including the exploitation of evolutionary trade-offs, targeting bacterial metabolism and studying the ancestral functions of antibiotic resistance determinants.
In this study, Brown et al. show that nutrient deprivation increases Plasmodium falciparum survival and tolerance to the antimalarial drug artemisinin.
Shigella spp. that are resistant to almost all antimicrobial classes are increasing in prevalence and becoming globally dominant. The situation is critical and highlights a trend that is mirrored by other enteric bacterial pathogens. New interventions to prevent and treat these infections are essential to tackle a potential public health catastrophe.
